NDN

Gene Symbol	NDN
Entrez Gene	4692
Alt Symbol	HsT16328, PWCR
Species	Human
Gene Type	protein-coding
Description	necdin, melanoma antigen (MAGE) family member
Other Description	Prader-Willi syndrome chromosome region|necdin|necdin homolog
Swissprots	B2R6Z5 Q99608
Accessions	BAA22660 EAW57610 Q99608 AK129654 AK312779 BAG35642 BC008750 AAH08750 HQ448156 ADQ32637 KJ534888 AHW56528 KJ535010 AHW56649 U35139 AAB39469 NM_002487 NP_002478
Function	Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle- promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences (By similarity). {ECO:0000250}.
Subcellular Location	Perikaryon. Nucleus. Note=Neural perikarya, translocates to the nucleus of postmitotic neurons and interacts with the nuclear matrix.
Tissue Specificity	Almost ubiquitous. Detected in fetal brain, lung, liver and kidney; in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Not detected in peripheral blood leukocytes. In brain, restricted to post- mitotic neurons.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Ndn CRISPR/Cas9 KO Plasmid (h) - sc-405902 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Ndn HDR Plasmid (h) - sc-405902-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ndn Double Nickase Plasmid (h) - sc-405902-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ndn Double Nickase Plasmid (h2) - sc-405902-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ndn CRISPR Activation Plasmid (h) - sc-405902-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Ndn CRISPR Activation Plasmid (h2) - sc-405902-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Ndn Lentiviral Activation Particles (h) - sc-405902-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ndn Lentiviral Activation Particles (h2) - sc-405902-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ndn siRNA (h) - sc-37318 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Ndn shRNA Plasmid (h) - sc-37318-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Ndn shRNA (h) Lentiviral Particles - sc-37318-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Necdin RNAi - H00004692-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Necdin RNAi - H00004692-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU013751 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15122 from Sigma-Aldrich Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15122 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07321 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr07321

NDN siRNA (Human) - CRH3107 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human NDN(NM_002487.2) - SHR003918 from Creative biogene Category siRNA Species Reactivities Human

NDN shRNA Plasmid (Human) - CHH3107 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

NDN miRNA 3'UTR clone - MiUTR1H-06691 from Creative biogene Species Reactivities Human

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