TNFSF12

Gene Symbol	TNFSF12
Entrez Gene	8742
Alt Symbol	APO3L, DR3LG, TWEAK
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor (ligand) superfamily, member 12
Other Description	APO3 ligand|APO3/DR3 ligand|TNF-related WEAK inducer of apoptosis|tumor necrosis factor ligand superfamily member 12
Swissprots	Q8WUZ7 O43508 Q8IZK7
Accessions	BAE16557 EAW90179 O43508 AF030099 AAC51923 AF055872 AAC39724 AI091441 AY358870 AAQ89229 BC019047 AAH19047 BC071837 AAH71837 BC104420 AAI04421 JF432764 ADZ15981 NM_003809 NP_003800 NR_037146
Function	Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. {ECO:0000269|PubMed:10085077, ECO:0000269|PubMed:23667509}.
Subcellular Location	Isoform TWE-PRIL: Cell membrane; Single-pass membrane protein.
Tissue Specificity	Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.
Top Pathways	Cytokine-cytokine receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TWEAK Antibody - 4437 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

TWEAK (FL-249) - sc-5558 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

TWEAK (S-20) - sc-12405 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

TWEAK (CARL-1) - sc-56248 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Fn14 (ITEM-4) - sc-56250 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Anti-TWEAK antibody - ab37170 from Abcam Prices $378.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TWEAK antibody - ab199419 from Abcam Prices $384.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TWEAK antibody - ab192668 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TWEAK antibody - ab109824 from Abcam Prices $370.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-TWEAK antibody - ab17519 from Abcam Prices $370.00 Sizes 50 µg Host Goat Clonality Polyclonal

Anti-TWEAK antibody - ab57926 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-TWEAK antibody - ab86287 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TWEAK antibody (Biotin) - ab83437 from Abcam Prices $370.00 Sizes 50 µg Host Goat Clonality Polyclonal

Anti-TWEAK antibody [CARL1] (Phycoerythrin) - ab199387 from Abcam Prices $370.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone CARL1

Anti-TWEAK antibody [CARL1] - Low endotoxin, Azide free - ab199405 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone CARL1

Anti-TWEAK antibody [EPR11228(2)] - N-terminal - ab183700 from Abcam Host Rabbit Clonality Monoclonal Clone EPR11228(2)

Anti-TNFSF12 / TWEAK Antibody (clone CARL-2) - LS-C106783 from LifeSpan Bioscience Prices $225.00, $305.00 Sizes 25 µg, 100 µg Host Mouse Clonality Monoclonal Clone CARL-2

Anti-TNFSF12 / TWEAK Antibody (aa57-106) - LS-C30024 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TNFSF12 / TWEAK Antibody - LS-C132766 from LifeSpan Bioscience Prices $365.00 Sizes 100 µg Host Rat Clonality Monoclonal

Anti-TNFSF12 / TWEAK Antibody - LS-C132767 from LifeSpan Bioscience Prices $445.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TNFSF12 / TWEAK Antibody (clone CARL-1) - LS-C41139 from LifeSpan Bioscience Prices $265.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone CARL-1

Anti-TNFSF12 / TWEAK Antibody (clone MTW-1) - LS-C188551 from LifeSpan Bioscience Prices $250.00 Sizes 100 µg Host Rat Clonality Monoclonal Clone MTW-1

Anti-TNFSF12 / TWEAK Antibody - LS-C191361 from LifeSpan Bioscience Prices $325.00 Sizes 50 µg Host Goat Clonality Polyclonal

Anti-TNFSF12 / TWEAK Antibody (aa35-84) - LS-C101636 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TNFSF12 / TWEAK Antibody (aa65-247, Biotin) - LS-C299764 from LifeSpan Bioscience Prices $435.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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