TNFSF12

Gene Symbol	TNFSF12
Entrez Gene	8742
Alt Symbol	APO3L, DR3LG, TWEAK
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor (ligand) superfamily, member 12
Other Description	APO3 ligand|APO3/DR3 ligand|TNF-related WEAK inducer of apoptosis|tumor necrosis factor ligand superfamily member 12
Swissprots	Q8WUZ7 O43508 Q8IZK7
Accessions	BAE16557 EAW90179 O43508 AF030099 AAC51923 AF055872 AAC39724 AI091441 AY358870 AAQ89229 BC019047 AAH19047 BC071837 AAH71837 BC104420 AAI04421 JF432764 ADZ15981 NM_003809 NP_003800 NR_037146
Function	Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. {ECO:0000269|PubMed:10085077, ECO:0000269|PubMed:23667509}.
Subcellular Location	Isoform TWE-PRIL: Cell membrane; Single-pass membrane protein.
Tissue Specificity	Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.
Top Pathways	Cytokine-cytokine receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TNFSF12 ELISA Kit - RAB0749 from Sigma-Aldrich Category ELISA Kit Prices $633.00 Sizes 1 kt

Rat TNFSF12 / TWEAK ELISA Kit (Sandwich ELISA) - LS-F6453 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 13.6 pg/ml Range 46.88-1500 pg/ml

Mouse/Human TNFSF12 / TWEAK ELISA Kit (Cell-Based ELISA) - LS-F3011 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 46.88-1500 pg/ml

Human TNFSF12 / TWEAK ELISA Kit (Sandwich ELISA) - LS-F207 from LifeSpan Bioscience Category ELISA Kit Prices $600.00, $1,100.00, $2,520.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 46.88 pg/ml Range 46.88-1500 pg/ml

Human TNFSF12 / TWEAK ELISA Kit (Sandwich ELISA) - LS-F603 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 46.88-1500 pg/ml

Mouse TNFSF12 / TWEAK ELISA Kit (Sandwich ELISA) - LS-F300 from LifeSpan Bioscience Category ELISA Kit Prices $620.00, $1,090.00, $2,380.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 0.274 pg/ml Range 46.88-1500 pg/ml

Human TNFSF12 / TWEAK ELISA Kit (Sandwich ELISA) - LS-F8914 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 6.4 pg/ml Range 46.88-1500 pg/ml

Rat TNFSF12 / TWEAK ELISA Kit (Sandwich ELISA) - LS-F2863 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 15.6 pg/ml Range 46.88-1500 pg/ml

Mouse TNFSF12 / TWEAK ELISA Kit (Sandwich ELISA) - LS-F2862 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 46.88-1500 pg/ml

Human TNFSF12 / TWEAK ELISA Kit (Sandwich ELISA) - LS-F2758 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 46.88-1500 pg/ml

Human TNFSF12 / TWEAK ELISA Kit (Sandwich ELISA) - LS-F12793 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 46.88-1500 pg/ml

Human TWEAK/TNFSF12 DuoSet ELISA - DY1090 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 62.50 - 4,000 pg/mL

Mouse TWEAK/TNFSF12 DuoSet ELISA - DY1237 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 15.60 - 1,000 pg/mL

TWEAK ELISA Kit (Human) : 96 Wells (OKAG00070) - OKAG00070 from Aviva Systems Biology Category ELISA Kit Prices $390.00 Sizes 96 wells Sensitivity 16 pg/mL Range 16-2,000 pg/mL

Soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK), Human, ELISA Kit - CSB-E16492h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

TNFSF12, Human, ELISA Kit - PB-0920 from ARP American Research Products Category ELISA Kit Prices $418.00 Sizes 96 t Sensitivity < 10 pg/ml Range 62.5pg/ml-4000pg/ml

Tumor necrosis factor ligand superfamily member 12, TNFSF12, Human, ELISA Kit - E1883h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Tumor Necrosis Factor Ligand Superfamily, Member 12 (TNFSF12), Human, ELISA Kit - SED933Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 11.3pg/mL Range 31.2-2,000pg/mL

Tumour Necrosis Factor Related Weak Inducer of Apoptosis, TWEAK, Human, ELISA Kit - E-EL-H2312 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 46.875 Range 78.125-5000pg/mL

Tumour Necrosis Factor Related Weak Inducer of Apoptosis, TWEAK, Rabbit, ELISA Kit - E-EL-RB0054 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Tumour Necrosis Factor Related Weak Inducer of Apoptosis, TWEAK, Chicken, ELISA Kit - E-EL-Ch0404 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Tumour Necrosis Factor Related Weak Inducer of Apoptosis, TWEAK, Porcine, ELISA Kit - E-EL-P1065 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Tumour Necrosis Factor Related Weak Inducer of Apoptosis, TWEAK, Monkey, ELISA Kit - E-EL-MK0342 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

TNFSF12 (Human) ELISA Kit - KA2198 from Acris Antibodies Category ELISA Kit Prices $650.00 Sizes 1 kit

Human TWEAK ELISA Kit - HT0563 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

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