| Gene Symbol | TNFSF12 |
|---|---|
| Entrez Gene | 8742 |
| Alt Symbol | APO3L, DR3LG, TWEAK |
| Species | Human |
| Gene Type | protein-coding |
| Description | tumor necrosis factor (ligand) superfamily, member 12 |
| Other Description | APO3 ligand|APO3/DR3 ligand|TNF-related WEAK inducer of apoptosis|tumor necrosis factor ligand superfamily member 12 |
| Swissprots | Q8WUZ7 O43508 Q8IZK7 |
| Accessions | BAE16557 EAW90179 O43508 AF030099 AAC51923 AF055872 AAC39724 AI091441 AY358870 AAQ89229 BC019047 AAH19047 BC071837 AAH71837 BC104420 AAI04421 JF432764 ADZ15981 NM_003809 NP_003800 NR_037146 |
| Function | Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. {ECO:0000269|PubMed:10085077, ECO:0000269|PubMed:23667509}. |
| Subcellular Location | Isoform TWE-PRIL: Cell membrane; Single-pass membrane protein. |
| Tissue Specificity | Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain. |
| Top Pathways | Cytokine-cytokine receptor interaction |
TNFSF12 293T Cell Transient Overexpression Lysate(Denatured) - H00008742-T01 from Acris Antibodies
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TWEAK/TNFSF12 Overexpression Lysate (Denatured) - H00008742-T01 from Novus Biologicals
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Cynomolgus / Human TNFSF12 HEK293 Cell Lysate (WB positive control) - 90094-C04HL-300 from Sino Biological
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Panoply™ Human TNFSF12 Knockdown Stable Cell Line - CSC-DC016373 from Creative biogene
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