TNFSF12

Gene Symbol	TNFSF12
Entrez Gene	8742
Alt Symbol	APO3L, DR3LG, TWEAK
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor (ligand) superfamily, member 12
Other Description	APO3 ligand|APO3/DR3 ligand|TNF-related WEAK inducer of apoptosis|tumor necrosis factor ligand superfamily member 12
Swissprots	Q8WUZ7 O43508 Q8IZK7
Accessions	BAE16557 EAW90179 O43508 AF030099 AAC51923 AF055872 AAC39724 AI091441 AY358870 AAQ89229 BC019047 AAH19047 BC071837 AAH71837 BC104420 AAI04421 JF432764 ADZ15981 NM_003809 NP_003800 NR_037146
Function	Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. {ECO:0000269|PubMed:10085077, ECO:0000269|PubMed:23667509}.
Subcellular Location	Isoform TWE-PRIL: Cell membrane; Single-pass membrane protein.
Tissue Specificity	Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.
Top Pathways	Cytokine-cytokine receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active TWEAK full length protein - ab9968 from Abcam Category Protein Prices $257.00 Sizes 25 µg Source E. coli

Dog TWEAK full length protein - ab177569 from Abcam Category Protein Prices $250.00 Sizes 25 µg Source Yeast Species Dog

Human TWEAK full length protein - ab191766 from Abcam Category Protein Source E. coli Species Human

Human TWEAK full length protein - ab123525 from Abcam Category Protein Source HEK 293 cells Species Human

Mouse TWEAK full length protein - ab184591 from Abcam Category Protein Source Yeast Species Mouse

Pig TWEAK protein fragment - ab169719 from Abcam Category Protein Source Yeast Species Pig

TNFSF12 / TWEAK Antibody Blocking Peptide - LS-E10660 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TNFSF12 / TWEAK Antibody Blocking Peptide - LS-E13095 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TWEAK/TNFSF12 Protein - H00008742-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TWEAK/TNFSF12 Recombinant Protein - H00008742-P01 from Novus Biologicals Category Protein

TWEAK/TNFSF12 Recombinant Protein - P4062 from Novus Biologicals Category Protein Prices $669.00 Sizes 10 µg Species Human

Recombinant Human TWEAK/TNFSF12 Protein - NBP1-99522 from Novus Biologicals Category Protein Prices $1.00, $209.00 Sizes 10 µg, 10 µg Source E. coli Species Human

TWEAK recombinant protein - GTX65293 from GeneTex Category Protein Prices $299.00 Sizes 10 μg Source E. coli Species Human

TWEAK Recombinant Protein (Active) - GTX48337-PRO from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

Recombinant Human TWEAK/TNFSF12 - 1090-TW-025 from R&D Systems Category Protein Source E. coli-derived, Arg93-His249, with an N-terminal Met and 6-His tag

Recombinant Human TWEAK/TNFSF12, CF - 1090-TW-025/CF from R&D Systems Category Protein Source E. coli-derived, Arg93-His249, with an N-terminal Met and 6-His tag

TNFSF12 Protein (OPPA02220) - OPPA02220 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source HEK293 (Human Embryonic Kidney Cell Line)

Cynomolgus TNFSF12 protein - orb139788 from Biorbyt Category Protein Prices $162.00, $357.00, $612.00 Sizes 5 μg, 20 μg, 50 μg Source Human Cells

Human TNFSF12 protein - orb80626 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Species Human

TNFSF12 Blocking Peptide - 33R-4986 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TNFSF12 Blocking Peptide - 33R-7519 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TWEAK protein - 30R-2584 from Fitzgerald Category Protein Prices $260.00 Sizes 10 µg Source E.coli Species Human

TWEAK protein - 30R-AT062 from Fitzgerald Category Protein Prices $95.00, $225.00 Sizes 5 µg, 25 µg Source E.coli

Human TNFSF12 Protein - abx069546 from Abbexa Category Protein Source E.coli Species Human

Human TNFSF12 Protein - abx069547 from Abbexa Category Protein Source E.coli Species Human

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