TNFSF12

Gene Symbol	TNFSF12
Entrez Gene	8742
Alt Symbol	APO3L, DR3LG, TWEAK
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor (ligand) superfamily, member 12
Other Description	APO3 ligand|APO3/DR3 ligand|TNF-related WEAK inducer of apoptosis|tumor necrosis factor ligand superfamily member 12
Swissprots	Q8WUZ7 O43508 Q8IZK7
Accessions	BAE16557 EAW90179 O43508 AF030099 AAC51923 AF055872 AAC39724 AI091441 AY358870 AAQ89229 BC019047 AAH19047 BC071837 AAH71837 BC104420 AAI04421 JF432764 ADZ15981 NM_003809 NP_003800 NR_037146
Function	Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. {ECO:0000269|PubMed:10085077, ECO:0000269|PubMed:23667509}.
Subcellular Location	Isoform TWE-PRIL: Cell membrane; Single-pass membrane protein.
Tissue Specificity	Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.
Top Pathways	Cytokine-cytokine receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TWEAK CRISPR/Cas9 KO Plasmid (h) - sc-401202 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TWEAK HDR Plasmid (h) - sc-401202-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TWEAK Double Nickase Plasmid (h) - sc-401202-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TWEAK Double Nickase Plasmid (h2) - sc-401202-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TWEAK CRISPR Activation Plasmid (h) - sc-401202-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TWEAK CRISPR Activation Plasmid (h2) - sc-401202-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TWEAK Lentiviral Activation Particles (h) - sc-401202-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TWEAK Lentiviral Activation Particles (h2) - sc-401202-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TWEAK siRNA (h) - sc-37522 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TWEAK shRNA Plasmid (h) - sc-37522-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TWEAK shRNA (h) Lentiviral Particles - sc-37522-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TWEAK/TNFSF12 RNAi - H00008742-R01 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU227381 from Sigma-Aldrich Category siRNA Prices $140.00, $140.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21761 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21761 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

TNFSF12 siRNA (Human) - CRH5760 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TNFSF12 - MBS8212049 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TWEAK HDR Plasmid (h2) - sc-401202-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TWEAK CRISPR/Cas9 KO Plasmid (h2) - sc-401202-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human TNFSF12 (NM_003809.2) - SHH432112 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human TNFSF12(NM_003809.2) - SHL085544 from Creative biogene Category siRNA Species Reactivities Human

Human TNFSF12 siRNA - orb266262 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TNFSF12 shRNA Plasmid (Human) - CHH5760 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

TNFSF12 miRNA 3'UTR clone - MiUTR1H-10609 from Creative biogene Species Reactivities Human

Search more