TNFSF12

Gene Symbol	TNFSF12
Entrez Gene	8742
Alt Symbol	APO3L, DR3LG, TWEAK
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor (ligand) superfamily, member 12
Other Description	APO3 ligand|APO3/DR3 ligand|TNF-related WEAK inducer of apoptosis|tumor necrosis factor ligand superfamily member 12
Swissprots	Q8WUZ7 O43508 Q8IZK7
Accessions	BAE16557 EAW90179 O43508 AF030099 AAC51923 AF055872 AAC39724 AI091441 AY358870 AAQ89229 BC019047 AAH19047 BC071837 AAH71837 BC104420 AAI04421 JF432764 ADZ15981 NM_003809 NP_003800 NR_037146
Function	Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. {ECO:0000269|PubMed:10085077, ECO:0000269|PubMed:23667509}.
Subcellular Location	Isoform TWE-PRIL: Cell membrane; Single-pass membrane protein.
Tissue Specificity	Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.
Top Pathways	Cytokine-cytokine receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-TNFSF12-cDNA-Clone - DC04788 from Abgent, a WuXi AppTec company Prices $180.90 Sizes 10 µg Species Human Accession BC019047

TNFSF12 - MBS1276439 from MyBioSource Species Human Accession BC019047

TNFSF12 - MBS1269173 from MyBioSource Species Human Accession BC104420

Human TNFSF12 cDNA clone(NM_003809.2) - CDFH020020 from Creative Biomart Species Human Accession NM_003809.2

Human TNFSF12 ORF clone(NM_003809.2) - CDCL186568 from Creative Biomart Species Human Accession NM_003809.2

Human TNFSF12 ORF Clone(NM_003809.2) - CDCL179244 from Creative Biomart Species Human Accession NM_003809.2

Human TNFSF12 ORF Clone(NM_003809.2) - CDCL179245 from Creative Biomart Species Human Accession NM_003809.2

Human TNFSF12 ORF Clone(NM_003809.2) - CDCR286529 from Creative Biomart Species Human Accession NM_003809.2

Human TNFSF12 ORF Clone(NM_003809.2) - CDCR286530 from Creative Biomart Species Human Accession NM_003809.2

human TNFSF12 ORF clone - CDCH093586 from Creative Biomart Species Human Accession NM_003809

human TNFSF12 ORF clone - CDCH093587 from Creative Biomart Species Human Accession NM_003809

human TNFSF12 ORF clone - CDCH093588 from Creative Biomart Species Human Accession NM_003809

human TNFSF12 ORF clone - CDCH093589 from Creative Biomart Species Human Accession NM_003809

Human TNFSF12 Gene ORF cDNA clone in cloning vector - HG10919-M from Sino Biological Species Human

Human TNFSF12 Gene ORF cDNA clone expression plasmid - HG10919-UT from Sino Biological Species Human

Human TNFSF12 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10919-NF from Sino Biological Species Human

Human TNFSF12 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10919-NM from Sino Biological Species Human

Human TNFSF12 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10919-CY from Sino Biological Species Human

Human TNFSF12 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10919-CF from Sino Biological Species Human

Human TNFSF12 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10919-ACG from Sino Biological Species Human

Human TNFSF12 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10919-CM from Sino Biological Species Human

Human TNFSF12 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10919-M-F from Sino Biological Species Human

Human TNFSF12 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG10919-M-N from Sino Biological Species Human Accession NM_003809.2

Human TNFSF12 Gene ORF cDNA clone expression plasmid, N-His tag - HG10919-NH from Sino Biological Species Human

Human TNFSF12 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10919-NY from Sino Biological Species Human

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