| Gene Symbol |
CTDSP1
|
| Entrez Gene |
58190
|
| Alt Symbol |
NIF3, NLI-IF, NLIIF, SCP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
|
| Other Description |
NLI-interacting factor 3|carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1|nuclear LIM interactor-interacting factor 3|small C-terminal domain phosphatase 1
|
| Swissprots |
Q7Z5Q4 Q9GZU7 C9IYG0 Q7Z5Q3
|
| Accessions |
AAG15404 EAW70615 EAW70616 EAW70617 EAW70618 Q9GZU7 AF217969 AAG17212 AF229162 AAG15402 AF258582 AAG23785 AK075090 AY279529 AAP34397 AY279530 AAP34398 BC012977 AAH12977 BX424971 BX446444 EU446878 ABZ92407 XM_011511569 XP_011509871 XM_011511570 XP_011509872 NM_001206878 NP_001193807 NM_021198 NP_067021 NM_182642 NP_872580 NM_001206879
|
| Function |
Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. {ECO:0000269|PubMed:12721286, ECO:0000269|PubMed:15681389}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12721286}. Note=Colocalizes with RNA polymerase II.
|
| Tissue Specificity |
Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta. {ECO:0000269|PubMed:15681389}.
|