Gene Symbol | CTDSP1 |
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Entrez Gene | 58190 |
Alt Symbol | NIF3, NLI-IF, NLIIF, SCP1 |
Species | Human |
Gene Type | protein-coding |
Description | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 |
Other Description | NLI-interacting factor 3|carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1|nuclear LIM interactor-interacting factor 3|small C-terminal domain phosphatase 1 |
Swissprots | Q7Z5Q4 Q9GZU7 C9IYG0 Q7Z5Q3 |
Accessions | AAG15404 EAW70615 EAW70616 EAW70617 EAW70618 Q9GZU7 AF217969 AAG17212 AF229162 AAG15402 AF258582 AAG23785 AK075090 AY279529 AAP34397 AY279530 AAP34398 BC012977 AAH12977 BX424971 BX446444 EU446878 ABZ92407 XM_011511569 XP_011509871 XM_011511570 XP_011509872 NM_001206878 NP_001193807 NM_021198 NP_067021 NM_182642 NP_872580 NM_001206879 |
Function | Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. {ECO:0000269|PubMed:12721286, ECO:0000269|PubMed:15681389}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:12721286}. Note=Colocalizes with RNA polymerase II. |
Tissue Specificity | Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta. {ECO:0000269|PubMed:15681389}. |
Human CTDSP1 full length protein - ab105591 from Abcam
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Human CTDSP1 full length protein - ab124856 from Abcam
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CTDSP1 / SCP1 Antibody Blocking Peptide - LS-E4417 from LifeSpan Bioscience
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CTDSP1 / SCP1 Antibody Blocking Peptide - LS-E23697 from LifeSpan Bioscience
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CTDSP1 / SCP1 Antibody Blocking Peptide - LS-E23696 from LifeSpan Bioscience
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CTDSP1 / SCP1 Antibody Blocking Peptide - LS-E26315 from LifeSpan Bioscience
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CTDSP1 / SCP1 Antibody Blocking Peptide - LS-E25913 from LifeSpan Bioscience
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CTDSP1 / SCP1 Antibody Blocking Peptide - LS-E9593 from LifeSpan Bioscience
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SCP1 / SYCP1 Antibody Blocking Peptide - LS-E4890 from LifeSpan Bioscience
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SCP1 / SYCP1 Antibody Blocking Peptide - LS-E21333 from LifeSpan Bioscience
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CTDSP1 Recombinant Protein - H00058190-P01 from Novus Biologicals
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Recombinant Human CTDSP1 Protein - NBP1-51081 from Novus Biologicals
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CTDSP1 Peptide - P3301 from Novus Biologicals
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CTDSP1-Antibody-N-term-Blocking-Peptide - BP16726a from Abgent, a WuXi AppTec company
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CTDSP1-V250-Antibody-C-term-blocking-peptide - BP8461b from Abgent, a WuXi AppTec company
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CTDSP1 blocking peptide - GTX89087-PEP from GeneTex
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Human CTDSP1 protein - orb168171 from Biorbyt
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CTDSP1 protein (His tag) - 80R-1770 from Fitzgerald
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CTDSP1 Blocking Peptide - abx063934 from Abbexa
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CTDSP1 Peptide - AC21-0743-P from Abcore
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CTDSP1 Peptide - AC21-1150-P from Abcore
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CTDSP1 (1-260, His-tag) - AR09953PU-L from Acris Antibodies
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CTDSP1 (1-260, His-tag) - AR09953PU-N from Acris Antibodies
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CTDSP1 - H00058190-P01-10 from Acris Antibodies
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CTDSP1 - H00058190-P01-25 from Acris Antibodies
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