CTDSP1
| Gene Symbol | CTDSP1 |
|---|---|
| Entrez Gene | 58190 |
| Alt Symbol | NIF3, NLI-IF, NLIIF, SCP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 |
| Other Description | NLI-interacting factor 3|carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1|nuclear LIM interactor-interacting factor 3|small C-terminal domain phosphatase 1 |
| Swissprots | Q7Z5Q4 Q9GZU7 C9IYG0 Q7Z5Q3 |
| Accessions | AAG15404 EAW70615 EAW70616 EAW70617 EAW70618 Q9GZU7 AF217969 AAG17212 AF229162 AAG15402 AF258582 AAG23785 AK075090 AY279529 AAP34397 AY279530 AAP34398 BC012977 AAH12977 BX424971 BX446444 EU446878 ABZ92407 XM_011511569 XP_011509871 XM_011511570 XP_011509872 NM_001206878 NP_001193807 NM_021198 NP_067021 NM_182642 NP_872580 NM_001206879 |
| Function | Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. {ECO:0000269|PubMed:12721286, ECO:0000269|PubMed:15681389}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:12721286}. Note=Colocalizes with RNA polymerase II. |
| Tissue Specificity | Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta. {ECO:0000269|PubMed:15681389}. |
CTDSP1 CRISPR/Cas9 KO Plasmid (h) - sc-406965 from Santa Cruz Biotechnology
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CTDSP1 HDR Plasmid (h) - sc-406965-HDR from Santa Cruz Biotechnology
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CTDSP1 Double Nickase Plasmid (h) - sc-406965-NIC from Santa Cruz Biotechnology
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CTDSP1 Double Nickase Plasmid (h2) - sc-406965-NIC-2 from Santa Cruz Biotechnology
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CTDSP1 CRISPR Activation Plasmid (h) - sc-406965-ACT from Santa Cruz Biotechnology
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CTDSP1 CRISPR Activation Plasmid (h2) - sc-406965-ACT-2 from Santa Cruz Biotechnology
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CTDSP1 Lentiviral Activation Particles (h) - sc-406965-LAC from Santa Cruz Biotechnology
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CTDSP1 Lentiviral Activation Particles (h2) - sc-406965-LAC-2 from Santa Cruz Biotechnology
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CTDSP1 siRNA (h) - sc-94748 from Santa Cruz Biotechnology
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CTDSP1 shRNA Plasmid (h) - sc-94748-SH from Santa Cruz Biotechnology
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CTDSP1 shRNA (h) Lentiviral Particles - sc-94748-V from Santa Cruz Biotechnology
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CTDSP1 RNAi - H00058190-R02 from Novus Biologicals
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CTDSP1 RNAi - H00058190-R01 from Novus Biologicals
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MISSION® esiRNA - EHU022741 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0934 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0071 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0072 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0933 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0070 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0935 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6725 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6725 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09543 from Sigma-Aldrich
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CTDSP1 siRNA (Human) - CRJ1705 from Cohesion Biosciences
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CTDSP1 - MBS8201760 from MyBioSource
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