GZMA

Gene Symbol GZMA
Entrez Gene 3001
Alt Symbol CTLA3, HFSP
Species Human
Gene Type protein-coding
Description granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
Other Description CTL tryptase|Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine protease)|HF|cytotoxic T-lymphocyte proteinase 1|fragmentin-1|granzyme A|h factor
Swissprots P12544 Q6IB36 A4PHN1
Accessions AAD00009 EAW54900 P12544 AB284134 BAF56159 BC015739 AAH15739 BP330335 CR456968 CAG33249 DQ893071 ABM83997 DQ896326 ABM87325 M18737 AAA52647 NM_006144 NP_006135
Function Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12524539, ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237}.
Subcellular Location Isoform alpha: Secreted. Cytoplasmic granule.
Top Pathways Neuroactive ligand-receptor interaction

Granzyme A Antibody - 4928 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of recombinant His-tagged Granzyme A (10 ng) and lysates from the natural killer cell line NK-92, using Granzyme A Antibody.

granzyme A (A-16) - sc-5510 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

granzyme A (CB9) - sc-56115 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
granzyme A (CB9): sc-56115. Immunofluorescence staining of human Cytotoxic T-Lymphocyte cells showing cytoplasmic granule (green color) localization. Kindly provided by Jerome Thiery and Judy Lieberman.

granzyme A (E-15) - sc-5511 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

granzyme A (GA6) - sc-56116 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
granzyme A (GA6): sc-56116. Western blot analysis of granzyme A expression in U-937 (A), AML-193 (B), K-562 (C) and HL-60 (D) whole cell lysates.

granzyme A (H-96) - sc-11434 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-Granzyme A antibody - ab191089 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Granzyme A antibody (ab191089) at 0.5 µg/mlLane 1 : Jurkat cell lysateLane 2 : CEM cell lysateLane 3 : Raji cell lysate

Anti-Granzyme A antibody - ab73420 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Granzyme A antibody (ab73420) at 1 µg/ml + Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Granzyme A antibody [GA6] - ab10870 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone GA6
ab10870 staining Granzyme A in human heart tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formalin and blocked with 10% serum for 30 minutes at 24°C; antigen retrieval was by heat mediation in a citrate buffer. Samples were incubated with primary antibody (1/50 in horse serum) for 16 hours at 4°C. A Biotin-conjugated horse anti-mouse IgG polyclonal (1/375) was used as the secondary antibody.See Abreview

Anti-GZMA / Granzyme A Antibody - LS-C24024 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-GZMA / Granzyme A Antibody (clone GA6) - LS-C11634 from LifeSpan Bioscience

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone GA6

Anti-GZMA / Granzyme A Antibody - LS-C36573 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-GZMA / Granzyme A Antibody (aa22-262) - LS-C36574 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-GZMA / Granzyme A Antibody - LS-C67061 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-GZMA / Granzyme A Antibody (clone GA6) - LS-C85161 from LifeSpan Bioscience

Prices $770.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone GA6

Anti-GZMA / Granzyme A Antibody (aa26-262) - LS-C182866 from LifeSpan Bioscience

Prices $650.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-GZMA / Granzyme A Antibody (aa29-260, FITC) - LS-C305555 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GZMA / Granzyme A Antibody - LS-C341984 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GZMA / Granzyme A Antibody (clone GA6) - LS-C202599 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone GA6

Anti-GZMA / Granzyme A Antibody (clone CB9) - LS-C41029 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone CB9
Human peripheral blood lymphocytes intracellular stained with purified CB9, followed by anti-mouse IgG FITC

Anti-GZMA / Granzyme A Antibody (aa61-110) - LS-C199018 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human heart tissue, using GRAA Antibody. The sample on the right was incubated with synthetic peptide.

Anti-GZMA / Granzyme A Antibody (aa29-260) - LS-C294323 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant GZMA / Granzyme A.

Anti-GZMA / Granzyme A Antibody (aa29-260, Biotin) - LS-C300920 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant GZMA / Granzyme A.

Anti-GZMA / Granzyme A Antibody (clone 4C6) - LS-C197389 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4C6
Detection limit for recombinant GST tagged GZMA is 3 ng/ml as a capture antibody.

Anti-GZMA / Granzyme A Antibody (C-Terminus) - LS-C117148 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
GZMA / Granzyme A antibody LS-C117148 Western blot of 721_B cell lysate.
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