| Gene Symbol |
GZMA
|
| Entrez Gene |
3001
|
| Alt Symbol |
CTLA3, HFSP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
|
| Other Description |
CTL tryptase|Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine protease)|HF|cytotoxic T-lymphocyte proteinase 1|fragmentin-1|granzyme A|h factor
|
| Swissprots |
P12544 Q6IB36 A4PHN1
|
| Accessions |
AAD00009 EAW54900 P12544 AB284134 BAF56159 BC015739 AAH15739 BP330335 CR456968 CAG33249 DQ893071 ABM83997 DQ896326 ABM87325 M18737 AAA52647 NM_006144 NP_006135
|
| Function |
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12524539, ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237}.
|
| Subcellular Location |
Isoform alpha: Secreted. Cytoplasmic granule.
|
| Top Pathways |
Neuroactive ligand-receptor interaction
|