GZMA

Gene Symbol	GZMA
Entrez Gene	3001
Alt Symbol	CTLA3, HFSP
Species	Human
Gene Type	protein-coding
Description	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
Other Description	CTL tryptase|Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine protease)|HF|cytotoxic T-lymphocyte proteinase 1|fragmentin-1|granzyme A|h factor
Swissprots	P12544 Q6IB36 A4PHN1
Accessions	AAD00009 EAW54900 P12544 AB284134 BAF56159 BC015739 AAH15739 BP330335 CR456968 CAG33249 DQ893071 ABM83997 DQ896326 ABM87325 M18737 AAA52647 NM_006144 NP_006135
Function	Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12524539, ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237}.
Subcellular Location	Isoform alpha: Secreted. Cytoplasmic granule.
Top Pathways	Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Granzyme A full length protein - ab157288 from Abcam Category Protein Prices $588.00 Sizes 10 µg Source E. coli Species Human

Human Granzyme A full length protein - ab132056 from Abcam Category Protein Source Wheat germ Species Human

Human Granzyme A full length protein - ab138792 from Abcam Category Protein Source Mammalian Species Human

Human Granzyme A full length protein - ab151654 from Abcam Category Protein Source HEK 293 cells Species Human

Human Granzyme A peptide - ab90219 from Abcam Category Peptide

Human Granzyme A protein fragment - ab114751 from Abcam Category Protein Source Wheat germ Species Human

GZMA / Granzyme A Antibody Blocking Peptide - LS-E19751 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Granzyme A Protein - H00003001-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Granzyme A Protein - H00003001-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

GZMA-Antibody-Center-K128-Blocking-peptide - BP11229c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Granzyme A blocking peptide - GTX88221-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Recombinant Human Granzyme A, CF - 2905-SE-010 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Cys26-Val262, with a C-terminal 10-His tag

Human Granzyme A protein - orb49422 from Biorbyt Category Protein Prices $408.00, $595.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source HEK293

Granzyme A Blocking Peptide - 33R-9256 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

GZMA Blocking Peptide - 33R-5360 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human Granzyme A Protein - abx066909 from Abbexa Category Protein Source Yeast Species Human

Granzyme A Peptide - AC21-1869-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Granzyme A (GZMA) - H00003001-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Granzyme A (GZMA) - H00003001-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Granzyme A (GZMA) - H00003001-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Granzyme A (GZMA) - H00003001-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Granzyme A (GZMA) - P6169 from Acris Antibodies Category Protein Prices $1,010.00 Sizes 100 µg Species Human

Granzyme A, Human, Recombinant - 19-C355 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source HEK293 Species Human

GZMA Peptide - 42-290P from ProSci Category Peptide Prices $175.00 Sizes 100 µg

GZMA fusion protein - ag1818 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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