GZMA

Gene Symbol	GZMA
Entrez Gene	3001
Alt Symbol	CTLA3, HFSP
Species	Human
Gene Type	protein-coding
Description	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
Other Description	CTL tryptase|Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine protease)|HF|cytotoxic T-lymphocyte proteinase 1|fragmentin-1|granzyme A|h factor
Swissprots	P12544 Q6IB36 A4PHN1
Accessions	AAD00009 EAW54900 P12544 AB284134 BAF56159 BC015739 AAH15739 BP330335 CR456968 CAG33249 DQ893071 ABM83997 DQ896326 ABM87325 M18737 AAA52647 NM_006144 NP_006135
Function	Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12524539, ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237}.
Subcellular Location	Isoform alpha: Secreted. Cytoplasmic granule.
Top Pathways	Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human GZMA Gene cDNA Clone - orb143450 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human-GZMA-cDNA-Clone - DC04170 from Abgent, a WuXi AppTec company Prices $353.70 Sizes 10 µg Species Human Accession BC015739

GZMA - MBS1271698 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC015739

Human GZMA ORF Clone(NM_006144.3) - CDCL165652 from Creative Biomart Species Human Accession NM_006144.3

Human GZMA Gene cDNA clone plasmid - HG13325-G from Sino Biological Species Human

Human GranzymeA/GZMA Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG13325-ACG from Sino Biological Species Human

Human GranzymeA/GZMA Gene ORF cDNA clone expression plasmid - HG13325-UT from Sino Biological Species Human

Human GranzymeA/GZMA Gene ORF cDNA clone expression plasmid, C-HA tag - HG13325-CY from Sino Biological Species Human

Human GranzymeA/GZMA Gene ORF cDNA clone expression plasmid, C-Flag tag - HG13325-G-F from Sino Biological Species Human

Human GZMA Gene cDNA Clone (full-length ORF Clone) expression ready, untagged - HG13325-G-N from Sino Biological Species Human Accession BC015739

Human GranzymeA/GZMA Gene ORF cDNA clone expression plasmid, N-Flag tag - HG13325-NF from Sino Biological Species Human

Human GranzymeA/GZMA Gene ORF cDNA clone expression plasmid, N-Myc tag - HG13325-NM from Sino Biological Species Human

Human GranzymeA/GZMA Gene ORF cDNA clone expression plasmid, C-Flag tag - HG13325-CF from Sino Biological Species Human

Human GranzymeA/GZMA Gene ORF cDNA clone expression plasmid, C-Myc tag - HG13325-CM from Sino Biological Species Human

Human GranzymeA/GZMA Gene ORF cDNA clone expression plasmid, N-His tag - HG13325-NH from Sino Biological Species Human

Human GranzymeA/GZMA Gene ORF cDNA clone expression plasmid, N-HA tag - HG13325-NY from Sino Biological Species Human

Human GranzymeA/GZMA Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG13325-ACR from Sino Biological Species Human

Human GranzymeA/GZMA Gene ORF cDNA clone expression plasmid, C-His tag - HG13325-CH from Sino Biological Species Human

Human GranzymeA ORF clone(NM_006144.3) - CDCL184465 from Creative biogene Species Human

Human GZMA ORF Clone (BC015739) - CDCS412573 from Creative biogene Species Human Accession P12544

Human GZMA ORF clone (BC015739) - CDCB157455 from Creative biogene Species Human

Human GZMA ORF clone (BC015739) - CDCB159846 from Creative biogene Species Human

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