GZMA

Gene Symbol GZMA
Entrez Gene 3001
Alt Symbol CTLA3, HFSP
Species Human
Gene Type protein-coding
Description granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
Other Description CTL tryptase|Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine protease)|HF|cytotoxic T-lymphocyte proteinase 1|fragmentin-1|granzyme A|h factor
Swissprots P12544 Q6IB36 A4PHN1
Accessions AAD00009 EAW54900 P12544 AB284134 BAF56159 BC015739 AAH15739 BP330335 CR456968 CAG33249 DQ893071 ABM83997 DQ896326 ABM87325 M18737 AAA52647 NM_006144 NP_006135
Function Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12524539, ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237}.
Subcellular Location Isoform alpha: Secreted. Cytoplasmic granule.
Top Pathways Neuroactive ligand-receptor interaction

granzyme A CRISPR/Cas9 KO Plasmid (h) - sc-403958 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

granzyme A HDR Plasmid (h) - sc-403958-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

granzyme A Double Nickase Plasmid (h) - sc-403958-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

granzyme A Double Nickase Plasmid (h2) - sc-403958-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

granzyme A CRISPR Activation Plasmid (h) - sc-403958-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

granzyme A CRISPR Activation Plasmid (h2) - sc-403958-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

granzyme A Lentiviral Activation Particles (h) - sc-403958-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

granzyme A Lentiviral Activation Particles (h2) - sc-403958-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

granzyme A siRNA (h) - sc-37431 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

granzyme A shRNA Plasmid (h) - sc-37431-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

granzyme A shRNA (h) Lentiviral Particles - sc-37431-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU040841 from Sigma-Aldrich

Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN9826 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9826 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

GZMA siRNA (Human) - CRH2036 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GZMA - MBS8209356 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human GZMA (NM_006144.3) - SHH309638 from Creative biogene

Category siRNA
Species Reactivities Human

GZMA shRNA Plasmid (Human) - CHH2036 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

GZMA miRNA 3'UTR clone - MiUTR3H-00991 from Creative biogene

Species Reactivities Human
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