GZMA

Gene Symbol	GZMA
Entrez Gene	3001
Alt Symbol	CTLA3, HFSP
Species	Human
Gene Type	protein-coding
Description	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
Other Description	CTL tryptase|Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine protease)|HF|cytotoxic T-lymphocyte proteinase 1|fragmentin-1|granzyme A|h factor
Swissprots	P12544 Q6IB36 A4PHN1
Accessions	AAD00009 EAW54900 P12544 AB284134 BAF56159 BC015739 AAH15739 BP330335 CR456968 CAG33249 DQ893071 ABM83997 DQ896326 ABM87325 M18737 AAA52647 NM_006144 NP_006135
Function	Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12524539, ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237}.
Subcellular Location	Isoform alpha: Secreted. Cytoplasmic granule.
Top Pathways	Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse GZMA / Granzyme A ELISA Kit (Sandwich ELISA) - LS-F4300 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 35 pg/ml Range 78.13-5000 pg/ml

Human GZMA / Granzyme A ELISA Kit (Sandwich ELISA) - LS-F9283 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 15.63 pg/ml Range 78.13-5000 pg/ml

Human GZMA / Granzyme A ELISA Kit (Sandwich ELISA) - LS-F11573 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 78.13-5000 pg/ml

Human Granzyme A ELISA kit - 55R-2251 from Fitzgerald Category ELISA Kit Prices $850.00 Sizes 96 wells

Human Granzyme A ELISA Kit - abx151729 from Abbexa Category ELISA Kit Sensitivity 5.9 pg/ml Range 15.625 pg/ml - 1000 pg/ml

Granzyme A (GZMA), Human, ELISA Kit - SEA599Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.054ng/mL Range 0.156-10ng/mL

Granzyme A, GZMA, Human, ELISA Kit - E0599h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Granzyme A, Human, ELISA - IB49681 from ARP American Research Products Category ELISA Kit Prices $802.00 Sizes 96 t

Granzymes A, Gzms-A, Human, ELISA Kit - CSB-E08715h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Granzyme A, GzmA, Human, ELISA Kit - E-EL-H1616 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 9.375 Range 15.625-1000pg/mL

granzyme A, Gzms-A, Mouse, ELISA Kit - E-EL-M0593 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Granzyme A, GzmA, Rabbit, ELISA Kit - E-EL-RB2260 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Granzyme A, GzmA, Chicken, ELISA Kit - E-EL-Ch0024 from ARP American Research Products Category ELISA Kit Prices $445.50 Sizes 96 t

Granzyme A, GzmA, Porcine, ELISA Kit - E-EL-P0402 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Granzyme A, GzmA, Guinea Pig, ELISA Kit - E-EL-GP0770 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Granzyme A, GzmA, Monkey, ELISA Kit - E-EL-MK2065 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Granzyme A - MBS494523 from MyBioSource Category ELISA Kit Prices $855.00 Sizes 12x8 tests

granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) , ELISA Kit - MBS704240 from MyBioSource Category ELISA Kit Prices $250.00, $550.00, $795.00, $2,890.00, $5,465.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human Gzms-A is typically less than 0.78 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 3.12 pg/ml-200 pg/ml.

Granzyme A (GZMA), ELISA Kit - MBS2023967 from MyBioSource Category ELISA Kit Prices $350.00, $525.00, $715.00, $2,915.00, $5,315.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of GZMA is typically less than 35pg/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 78-5,000pg/mL

Granzyme A (GZMA), ELISA Kit - MBS2600238 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Granzyme A (GZMA), ELISA Kit - MBS260923 from MyBioSource Category ELISA Kit Prices $290.00, $450.00, $1,755.00, $3,150.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.05 ng/ml. Range 10 ng/ml-0.156 ng/ml

Granzyme A (GZMA), ELISA Kit - MBS265283 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Granzyme A (GZMA), ELISA Kit - MBS2019689 from MyBioSource Category ELISA Kit Prices $345.00, $515.00, $695.00, $2,840.00, $5,180.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 6.2pg/mL. Range 15.63-1000pg/mL

Granzyme A (GZMA), ELISA Kit - MBS262020 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Granzyme A (GZMA), ELISA Kit - MBS265364 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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