PSMD10

Gene Symbol	PSMD10
Entrez Gene	5716
Alt Symbol	dJ889N15.2, p28, p28(GANK)
Species	Human
Gene Type	protein-coding
Description	proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
Other Description	26S proteasome non-ATPase regulatory subunit 10|26S proteasome regulatory subunit p28|ankyrin repeat protein|gankyrin|hepatocellular carcinoma-associated protein p28-II
Swissprots	Q8IZK9 Q5U0B2 O75832
Accessions	CAV33747 EAX02697 EAX02698 O75832 AB009619 BAA33215 AK058108 AK295996 BAG58771 AK309326 AY057056 AAL25260 BC011960 AAH11960 BI114640 BQ217943 BT019689 AAV38495 D83197 BAA34594 GQ129344 ACT64478 GQ129345 ACT64479 R15438 NM_002814 NP_002805 NM_170750 NP_736606
Function	Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:18040287}. Nucleus {ECO:0000269|PubMed:18040287}.
Tissue Specificity	Tends to be up-regulated in cancer cells with RAS mutations, including lung cancers and adenocarconimas (at protein level). {ECO:0000269|PubMed:10613832, ECO:0000269|PubMed:20628200}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PSMD10-Over-expression-Lysate - LY11998a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

PSMD10 293T Cell Transient Overexpression Lysate(Denatured) - H00005716-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

PSMD10 overexpression lysate - LY406867 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PSMD10 293 Cell Lysate - 404052 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

PSMD10 293 Cell Lysate - 408927 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Gankyrin Overexpression Lysate (Native) - NBL1-14895 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

PSMD10 Over-expression Lysate Product - GWB-9E9564 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

PSMD10 Over-expression Lysate Product - GWB-3869D0 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Gankyrin Overexpression Lysate (Native) - NBP2-05202 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Gankyrin Overexpression Lysate (Denatured) - H00005716-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Gankyrin Overexpression Lysate (Denatured) - H00005716-T03 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Gankyrin Overexpression Lysate (Denatured) - H00005716-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human PSMD10 Knockdown Stable Cell Line - CSC-DC012603 from Creative biogene Category Cell Line Species Human

Human PSMD10 Knockout Cell Line-HeLa - CSC-RT1706 from Creative biogene Category Cell Line Species Human

PSMD10 KO Cell Lysate-HeLa - CLKO-1553 from Creative biogene Category Cell Lysate

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