| Gene Symbol | PSMD10 |
|---|---|
| Entrez Gene | 5716 |
| Alt Symbol | dJ889N15.2, p28, p28(GANK) |
| Species | Human |
| Gene Type | protein-coding |
| Description | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 |
| Other Description | 26S proteasome non-ATPase regulatory subunit 10|26S proteasome regulatory subunit p28|ankyrin repeat protein|gankyrin|hepatocellular carcinoma-associated protein p28-II |
| Swissprots | Q8IZK9 Q5U0B2 O75832 |
| Accessions | CAV33747 EAX02697 EAX02698 O75832 AB009619 BAA33215 AK058108 AK295996 BAG58771 AK309326 AY057056 AAL25260 BC011960 AAH11960 BI114640 BQ217943 BT019689 AAV38495 D83197 BAA34594 GQ129344 ACT64478 GQ129345 ACT64479 R15438 NM_002814 NP_002805 NM_170750 NP_736606 |
| Function | Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:18040287}. Nucleus {ECO:0000269|PubMed:18040287}. |
| Tissue Specificity | Tends to be up-regulated in cancer cells with RAS mutations, including lung cancers and adenocarconimas (at protein level). {ECO:0000269|PubMed:10613832, ECO:0000269|PubMed:20628200}. |