PSMD10

Gene Symbol PSMD10
Entrez Gene 5716
Alt Symbol dJ889N15.2, p28, p28(GANK)
Species Human
Gene Type protein-coding
Description proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
Other Description 26S proteasome non-ATPase regulatory subunit 10|26S proteasome regulatory subunit p28|ankyrin repeat protein|gankyrin|hepatocellular carcinoma-associated protein p28-II
Swissprots Q8IZK9 Q5U0B2 O75832
Accessions CAV33747 EAX02697 EAX02698 O75832 AB009619 BAA33215 AK058108 AK295996 BAG58771 AK309326 AY057056 AAL25260 BC011960 AAH11960 BI114640 BQ217943 BT019689 AAV38495 D83197 BAA34594 GQ129344 ACT64478 GQ129345 ACT64479 R15438 NM_002814 NP_002805 NM_170750 NP_736606
Function Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:18040287}. Nucleus {ECO:0000269|PubMed:18040287}.
Tissue Specificity Tends to be up-regulated in cancer cells with RAS mutations, including lung cancers and adenocarconimas (at protein level). {ECO:0000269|PubMed:10613832, ECO:0000269|PubMed:20628200}.

PSMD10/Gankyrin Antibody - 12985 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using PSMD10/Gankyrin Antibody.

gankyrin (D-11) - sc-373735 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
gankyrin (D-11): sc-373735. Western blot analysis of gankyrin expression in non-transfected: sc-117752 (A) and mouse gankyrin transfected: sc-120400 (B) 293T whole cell lysates.

gankyrin (A-8) - sc-166376 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
gankyrin (A-8): sc-166376. Western blot analysis of gankyrin expression in non-transfected 293T: sc-117752 (A), mouse gankyrin transfected 293T: sc-120400 (B) and HeLa (C) whole cell lysates.

gankyrin (3A6C2) - sc-101498 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
gankyrin (3A6C2): sc-101498. Western blot analysis of gankyrin expression in HeLa (A), K-562 (B), HL-60 (C), ES-2 (D), JAR (E), Caki-1 (F) and Hep G2 (G) whole cell lysates.

gankyrin (G-2) - sc-166213 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
gankyrin (G-2): sc-166213. Western blot analysis of gankyrin expression in non-transfected: sc-117752 (A) and mouse gankyrin transfected: sc-120400 (B) 293T whole cell lysates.

gankyrin (N-13) - sc-28479 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
gankyrin (N-13): sc-28479. Western blot analysis of gankyrin expression in non-transfected: sc-117752 (A) and mouse gankyrin transfected: sc-120400 (B) 293T whole cell lysates.

gankyrin (H-231) - sc-8991 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
gankyrin (H-231): sc-8991. Immunoperoxidase staining of formalin fixed, paraffin-embedded human urinary bladder tissue showing nuclear and cytoplasmic staining of surface epthelial cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

Anti-Proteasome 26S S10 antibody - ab196688 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Proteasome 26S S10 antibody (ab196688) at 1/500 dilution + SW620 cell extract

Anti-Proteasome 26S S10 antibody - ab58116 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Proteasome 26S S10 antibody (ab58116) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human tonsil.

Anti-Proteasome 26S S10 antibody - ab154676 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Proteasome 26S S10 antibody (ab154676) at 1/1000 dilutionLane 1 : HeLa whole cell lysateLane 2 : HepG2 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-Proteasome 26S S10 antibody - ab167317 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-Proteasome 26S S10 antibody (ab167317) at 1 µg/ml + K562 cell lysate at 50 µg

Anti-Proteasome 26S S10 antibody - ab123278 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Proteasome 26S S10 antibody (ab123278) at 1/100 dilution + A549 cell line lysates at 35 µgdeveloped using the ECL technique

Anti-Proteasome 26S S10 antibody - ab98002 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Proteasome 26S S10 antibody (ab98002) at 1 µg/ml (5% skim milk/ PBS buffer) + ACHN cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-Proteasome 26S S10 antibody [3F6] - ab118009 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3F6
ab118009 at 1/50 dilution, staining Proteasome 26S S10 in Paraffin-embedded Human breast adenocarcinoma tissue Immunohistochemistry.

Anti-Proteasome 26S S10 antibody [EPR14455] - ab182576 from Abcam

Prices $99.00, $357.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14455
All lanes : Anti-Proteasome 26S S10 antibody [EPR14455] (ab182576) at 1/10000 dilutionLane 1 : HeLa cell lysateLane 2 : HepG2 cell lysateLane 3 : K562 cell lysateLane 4 : 293 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-Proteasome 26S S10 antibody [EPR14456(2)] - ab188315 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14456(2)
Flow cytometric analysis of HeLa cells fixed in 2% paraformaldehyde labeling Proteasome 26S S10 with ab188315 at 1/110 dilution and Goat anti-rabbit IgG (FITC) at 1/150 dilution.  Rabbit monoclonal IgG was used as an isotype control.

Anti-PSMD10 / Gankyrin Antibody (clone 3F6) - LS-C114857 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3F6
IHC of paraffin-embedded Adenocarcinoma of ovary tissue using anti-PSMD10 mouse monoclonal antibody. (Dilution 1:50).

Anti-PSMD10 / Gankyrin Antibody (aa43-76) - LS-C344212 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical of paraffin-embedded H.testis section using PSMD10 Antibody. Antibody was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.

Anti-PSMD10 / Gankyrin Antibody (aa183-213) - LS-C162240 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of PSMD10 (arrow) using rabbit polyclonal PSMD10 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the PSMD10 gene.

Anti-PSMD10 / Gankyrin Antibody (clone 4B5) IHC-plus™ - LS-B10019 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 4B5
IHC with PSMD10 antibody on frozen human tonsil.

Anti-PSMD10 / Gankyrin Antibody (Internal, Biotin) - LS-C140889 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PSMD10 / Gankyrin Antibody (Internal, DY650) - LS-C140890 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PSMD10 / Gankyrin Antibody (Internal, DY488) - LS-C140891 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PSMD10 / Gankyrin Antibody (Internal, HRP) - LS-C140892 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PSMD10 / Gankyrin Antibody (Internal, DY550) - LS-C140893 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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