PSMD10

Gene Symbol	PSMD10
Entrez Gene	5716
Alt Symbol	dJ889N15.2, p28, p28(GANK)
Species	Human
Gene Type	protein-coding
Description	proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
Other Description	26S proteasome non-ATPase regulatory subunit 10|26S proteasome regulatory subunit p28|ankyrin repeat protein|gankyrin|hepatocellular carcinoma-associated protein p28-II
Swissprots	Q8IZK9 Q5U0B2 O75832
Accessions	CAV33747 EAX02697 EAX02698 O75832 AB009619 BAA33215 AK058108 AK295996 BAG58771 AK309326 AY057056 AAL25260 BC011960 AAH11960 BI114640 BQ217943 BT019689 AAV38495 D83197 BAA34594 GQ129344 ACT64478 GQ129345 ACT64479 R15438 NM_002814 NP_002805 NM_170750 NP_736606
Function	Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:18040287}. Nucleus {ECO:0000269|PubMed:18040287}.
Tissue Specificity	Tends to be up-regulated in cancer cells with RAS mutations, including lung cancers and adenocarconimas (at protein level). {ECO:0000269|PubMed:10613832, ECO:0000269|PubMed:20628200}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Proteasome 26S S10 full length protein - ab78763 from Abcam Category Protein Source E. coli Species Human

Human Proteasome 26S S10 full length protein - ab116427 from Abcam Category Protein Source E. coli Species Human

PSMD10 / Gankyrin Antibody Blocking Peptide - LS-E3410 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PSMD10 / Gankyrin Antibody Blocking Peptide - LS-E20512 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PSMD10 / Gankyrin Antibody Blocking Peptide - LS-E20513 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Gankyrin Partial Recombinant Protein - H00005716-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Gankyrin Recombinant Protein - H00005716-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Gankyrin Recombinant Protein - H00005716-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Gankyrin Protein - NBC1-18518 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

PSMD10-Antibody-C-term-Blocking-Peptide - BP14586b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PSMD10 Protein (OPPA01830) - OPPA01830 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human PSMD10 protein - orb90254 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Source E.coli Species Human

Human PSMD10 protein - orb49401 from Biorbyt Category Protein Prices $306.00, $680.00, $2,321.00, $3,281.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human PSMD10 protein - orb246229 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Gankyrin protein - 30R-1204 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

Psmd10 Blocking Peptide - 33R-4354 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PSMD10 Blocking Peptide - 33R-6101 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PSMD10 / Gankyrin (1-226) - AR09028PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

PSMD10 / Gankyrin (1-226) - AR09028PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

PSMD10 / Gankyrin - H00005716-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PSMD10 / Gankyrin - H00005716-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PSMD10 / Gankyrin - H00005716-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

PSMD10 / Gankyrin - H00005716-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PSMD10 / Gankyrin - H00005716-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PSMD10 / Gankyrin - H00005716-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Search more