ZBP1

Gene Symbol	ZBP1
Entrez Gene	81030
Alt Symbol	C20orf183, DAI, DLM-1, DLM1
Species	Human
Gene Type	protein-coding
Description	Z-DNA binding protein 1
Other Description	DNA-dependent activator of IFN-regulatory factors|DNA-dependent activator of IRFs|DNA-dependent activator of interferon regulatory factors|Z-DNA-binding protein 1|tumor stroma and activated macrophage protein DLM-1
Swissprots	Q5JY39 Q9H171 Q9BYW4 F5GYT1 B3KVA1 A2A2F7
Accessions	EAW75509 EAW75510 EAW75511 EAW75512 EAW75513 Q9H171 AI659939 AI925506 AJ300575 CAC18810 AK122761 BAG53713 AK128405 AK290918 BAF83607 AK314062 AX775973 CAE11686 AX775975 CAE11687 BC028218 AAH28218 BC131706 AAI31707 BF511589 CT002036 DA674238 DA676308 DB331848 XM_011529057 XP_011527359 XM_011529058 XP_011527360 XM_011529059 XP_011527361 XR_936633 XR_936634 XR_936636 XR_936637 XR_936638 XR_936639 XR_936640 NM_001160417 NP_001153889 NM_001160418 NP_001153890 NM_001160419 NP_001153891 NM_030776 NP_110403
Function	Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity). {ECO:0000250}.
Tissue Specificity	Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. Expressed to a lesser extent in thymus, lung and liver.
Top Pathways	Cytosolic DNA-sensing pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ZBP1 (H-300) - sc-67259 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

ZBP1 (T-16) - sc-50690 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

ZBP1 (G-15) - sc-50686 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

ZBP1 (E-13) - sc-50685 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Z DNA binding protein antibody - ab81526 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Z DNA binding protein antibody - ab118361 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-Z DNA binding protein antibody - ab32927 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ZBP1/DLM-1/DAI Antibody - AF6309 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Sheep Clonality Polyclonal

ZBP1/DLM-1/DAI Antibody - NBP1-76854 from Novus Biologicals Prices $329.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

ZBP1/DLM-1/DAI Antibody (2C10) - H00081030-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2C10

ZBP1/DLM-1/DAI Antibody - 26170002 from Novus Biologicals Prices $429.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Z DNA binding protein Antibody - bs-13559R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit

Z DNA binding protein Antibody, ALEXA FLUOR® 350 Conjugated - bs-13559R-A350 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit

Z DNA binding protein Antibody, ALEXA FLUOR® 488 Conjugated - bs-13559R-A488 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit

Z DNA binding protein Antibody, ALEXA FLUOR® 555 Conjugated - bs-13559R-A555 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit

Z DNA binding protein Antibody, ALEXA FLUOR® 647 Conjugated - bs-13559R-A647 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit

Z DNA binding protein Antibody, Cy3 Conjugated - bs-13559R-Cy3 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit

Z DNA binding protein Antibody, Cy5 Conjugated - bs-13559R-Cy5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit

Z DNA binding protein Antibody, Cy5.5 Conjugated - bs-13559R-Cy5.5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit

Z DNA binding protein Antibody, Cy7 Conjugated - bs-13559R-Cy7 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit

Z DNA binding protein Antibody, FITC Conjugated - bs-13559R-FITC from Bioss Prices $369.00 Sizes 100 µl Host Rabbit

Z DNA binding protein Antibody, Biotin Conjugated - bs-13559R-Biotin from Bioss Prices $349.00 Sizes 100 µl Host Rabbit

Z DNA binding protein Antibody, HRP Conjugated - bs-13559R-HRP from Bioss Prices $369.00 Sizes 100 µl Host Rabbit

Monoclonal Anti-ZBP1 antibody produced in mouse - SAB1402632 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2C10

Anti-ZBP1 antibody produced in rabbit - HPA041256 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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