| Gene Symbol | ZBP1 |
|---|---|
| Entrez Gene | 81030 |
| Alt Symbol | C20orf183, DAI, DLM-1, DLM1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Z-DNA binding protein 1 |
| Other Description | DNA-dependent activator of IFN-regulatory factors|DNA-dependent activator of IRFs|DNA-dependent activator of interferon regulatory factors|Z-DNA-binding protein 1|tumor stroma and activated macrophage protein DLM-1 |
| Swissprots | Q5JY39 Q9H171 Q9BYW4 F5GYT1 B3KVA1 A2A2F7 |
| Accessions | EAW75509 EAW75510 EAW75511 EAW75512 EAW75513 Q9H171 AI659939 AI925506 AJ300575 CAC18810 AK122761 BAG53713 AK128405 AK290918 BAF83607 AK314062 AX775973 CAE11686 AX775975 CAE11687 BC028218 AAH28218 BC131706 AAI31707 BF511589 CT002036 DA674238 DA676308 DB331848 XM_011529057 XP_011527359 XM_011529058 XP_011527360 XM_011529059 XP_011527361 XR_936633 XR_936634 XR_936636 XR_936637 XR_936638 XR_936639 XR_936640 NM_001160417 NP_001153889 NM_001160418 NP_001153890 NM_001160419 NP_001153891 NM_030776 NP_110403 |
| Function | Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity). {ECO:0000250}. |
| Tissue Specificity | Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. Expressed to a lesser extent in thymus, lung and liver. |
| Top Pathways | Cytosolic DNA-sensing pathway |
ZBP1 CRISPR/Cas9 KO Plasmid (h) - sc-406434 from Santa Cruz Biotechnology
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ZBP1 HDR Plasmid (h) - sc-406434-HDR from Santa Cruz Biotechnology
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ZBP1 Double Nickase Plasmid (h) - sc-406434-NIC from Santa Cruz Biotechnology
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ZBP1 Double Nickase Plasmid (h2) - sc-406434-NIC-2 from Santa Cruz Biotechnology
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ZBP1 CRISPR Activation Plasmid (h) - sc-406434-ACT from Santa Cruz Biotechnology
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ZBP1 CRISPR Activation Plasmid (h2) - sc-406434-ACT-2 from Santa Cruz Biotechnology
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ZBP1 Lentiviral Activation Particles (h) - sc-406434-LAC from Santa Cruz Biotechnology
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ZBP1 Lentiviral Activation Particles (h2) - sc-406434-LAC-2 from Santa Cruz Biotechnology
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ZBP1 siRNA (h) - sc-61822 from Santa Cruz Biotechnology
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ZBP1 shRNA Plasmid (h) - sc-61822-SH from Santa Cruz Biotechnology
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ZBP1 shRNA (h) Lentiviral Particles - sc-61822-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU123091 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN23052 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23052 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05894 from Sigma-Aldrich
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ZBP1 siRNA (Human) - CRJ2945 from Cohesion Biosciences
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ZBP1 - MBS8230070 from MyBioSource
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shRNA set against Human ZBP1 (NM_030776.2) - SHH448888 from Creative biogene
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ZBP1 shRNA Plasmid (Human) - CHJ2945 from Cohesion Biosciences
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ZBP1 miRNA 3'UTR clone - MiUTR1H-11366 from Creative biogene
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ZBP1 miRNA 3'UTR clone - MiUTR1H-11367 from Creative biogene
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ZBP1 miRNA 3'UTR clone - MiUTR1H-11368 from Creative biogene
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ZBP1 miRNA 3'UTR clone - MiUTR4H-TG12805 from Creative biogene
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