ZBP1

Gene Symbol	ZBP1
Entrez Gene	81030
Alt Symbol	C20orf183, DAI, DLM-1, DLM1
Species	Human
Gene Type	protein-coding
Description	Z-DNA binding protein 1
Other Description	DNA-dependent activator of IFN-regulatory factors|DNA-dependent activator of IRFs|DNA-dependent activator of interferon regulatory factors|Z-DNA-binding protein 1|tumor stroma and activated macrophage protein DLM-1
Swissprots	Q5JY39 Q9H171 Q9BYW4 F5GYT1 B3KVA1 A2A2F7
Accessions	EAW75509 EAW75510 EAW75511 EAW75512 EAW75513 Q9H171 AI659939 AI925506 AJ300575 CAC18810 AK122761 BAG53713 AK128405 AK290918 BAF83607 AK314062 AX775973 CAE11686 AX775975 CAE11687 BC028218 AAH28218 BC131706 AAI31707 BF511589 CT002036 DA674238 DA676308 DB331848 XM_011529057 XP_011527359 XM_011529058 XP_011527360 XM_011529059 XP_011527361 XR_936633 XR_936634 XR_936636 XR_936637 XR_936638 XR_936639 XR_936640 NM_001160417 NP_001153889 NM_001160418 NP_001153890 NM_001160419 NP_001153891 NM_030776 NP_110403
Function	Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity). {ECO:0000250}.
Tissue Specificity	Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. Expressed to a lesser extent in thymus, lung and liver.
Top Pathways	Cytosolic DNA-sensing pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Z DNA binding protein full length protein - ab153528 from Abcam Category Protein Source Wheat germ Species Human

Human Z DNA binding protein protein fragment - ab153529 from Abcam Category Protein Source Wheat germ Species Human

Human ZBP1 R protein - orb163337 from Biorbyt Category Protein Prices $408.00, $595.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source E. coli Species Human

Human ZBP1 Protein - abx069716 from Abbexa Category Protein Source E.coli Species Human

ZBP1 - H00081030-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ZBP1 - H00081030-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ZBP1 - H00081030-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ZBP1 - H00081030-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Z-DNA Binding Protein 1 (ZBP1), Human - 20-7816 from ARP American Research Products Category Protein Prices $549.00 Sizes 50 µg Source E.coli Species Human

ZBP1 Peptide - 4401P from ProSci Category Peptide Species Human

ZBP1 fusion protein - Ag4119 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human ZBP1 Protein - BP002666-C282 from Syd Labs Category Protein Prices $180.00, $528.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Human

Recombinant Human ZBP1, GST-tagged - ZBP1-3779H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Z-DNA Binding Protein 1 (ZBP1) - RPB552Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Z-DNA Binding Protein 1 (ZBP1) - RPB552Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Z-DNA-binding protein 1(ZBP1) - CSB-YP861990HU CSB-EP861990HU CSB-BP861990HU CSB-MP861990HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ZBP1 (transcript variant 1) - TP720577 from Acris Antibodies Category Protein Prices $299.00 Sizes 10 µg Source E. coli Species Human

ZBP1 (full length, N-term HIS tag, transcript variant 1) - TP760418 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

Z-DNA Binding Protein 1 (ZBP1), Recombinant Protein - MBS2009379 from MyBioSource Category Protein Prices $260.00, $475.00, $695.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Z-DNA-binding protein 1 (ZBP1) , Recombinant Protein - MBS1351729 from MyBioSource Category Protein Prices $1,945.00, $1,945.00, $2,410.00, $2,410.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

ZBP1/DLM-1/DAI Recombinant Protein Antigen - NBP2-14793PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ZBP1 Recombinant Protein (OPCD07995) - OPCD07995 from Aviva Systems Biology Category Protein Source E.coli Species Human

ZBP1 Recombinant Protein - 91-262 from ProSci Category Protein Prices $525.00 Sizes 50 µg Source E. coli Species Human

Recombinant Human Z-DNA Binding Protein 1,ZBP1 (C-6His) - AP75014 from Signalway Antibody Category Protein Prices $349.00, $749.00, $2,289.00, $3,209.00 Sizes 10 µg, 50 µg, 500 µg, 1 mg Source E.coli Species Human

Human ZBP1 protein - orb392728 from Biorbyt Category Protein Species Human

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