| Gene Symbol |
ZBP1
|
| Entrez Gene |
81030
|
| Alt Symbol |
C20orf183, DAI, DLM-1, DLM1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Z-DNA binding protein 1
|
| Other Description |
DNA-dependent activator of IFN-regulatory factors|DNA-dependent activator of IRFs|DNA-dependent activator of interferon regulatory factors|Z-DNA-binding protein 1|tumor stroma and activated macrophage protein DLM-1
|
| Swissprots |
Q5JY39 Q9H171 Q9BYW4 F5GYT1 B3KVA1 A2A2F7
|
| Accessions |
EAW75509 EAW75510 EAW75511 EAW75512 EAW75513 Q9H171 AI659939 AI925506 AJ300575 CAC18810 AK122761 BAG53713 AK128405 AK290918 BAF83607 AK314062 AX775973 CAE11686 AX775975 CAE11687 BC028218 AAH28218 BC131706 AAI31707 BF511589 CT002036 DA674238 DA676308 DB331848 XM_011529057 XP_011527359 XM_011529058 XP_011527360 XM_011529059 XP_011527361 XR_936633 XR_936634 XR_936636 XR_936637 XR_936638 XR_936639 XR_936640 NM_001160417 NP_001153889 NM_001160418 NP_001153890 NM_001160419 NP_001153891 NM_030776 NP_110403
|
| Function |
Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. Expressed to a lesser extent in thymus, lung and liver.
|
| Top Pathways |
Cytosolic DNA-sensing pathway
|