| Gene Symbol | ZBP1 |
|---|---|
| Entrez Gene | 81030 |
| Alt Symbol | C20orf183, DAI, DLM-1, DLM1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Z-DNA binding protein 1 |
| Other Description | DNA-dependent activator of IFN-regulatory factors|DNA-dependent activator of IRFs|DNA-dependent activator of interferon regulatory factors|Z-DNA-binding protein 1|tumor stroma and activated macrophage protein DLM-1 |
| Swissprots | Q5JY39 Q9H171 Q9BYW4 F5GYT1 B3KVA1 A2A2F7 |
| Accessions | EAW75509 EAW75510 EAW75511 EAW75512 EAW75513 Q9H171 AI659939 AI925506 AJ300575 CAC18810 AK122761 BAG53713 AK128405 AK290918 BAF83607 AK314062 AX775973 CAE11686 AX775975 CAE11687 BC028218 AAH28218 BC131706 AAI31707 BF511589 CT002036 DA674238 DA676308 DB331848 XM_011529057 XP_011527359 XM_011529058 XP_011527360 XM_011529059 XP_011527361 XR_936633 XR_936634 XR_936636 XR_936637 XR_936638 XR_936639 XR_936640 NM_001160417 NP_001153889 NM_001160418 NP_001153890 NM_001160419 NP_001153891 NM_030776 NP_110403 |
| Function | Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity). {ECO:0000250}. |
| Tissue Specificity | Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. Expressed to a lesser extent in thymus, lung and liver. |
| Top Pathways | Cytosolic DNA-sensing pathway |
ZBP1 - MBS1265969 from MyBioSource
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ZBP1 - MBS1271015 from MyBioSource
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Human ZBP1 cDNA clone(NM_001160417.1) - CDFH021457 from Creative Biomart
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Human ZBP1 cDNA clone(NM_001160418.1) - CDFH021458 from Creative Biomart
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Human ZBP1 ORF Clone(NM_001160417.1) - CDCR353970 from Creative Biomart
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Human ZBP1 ORF Clone(NM_001160417.1) - CDCR353971 from Creative Biomart
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Human ZBP1 ORF Clone(NM_001160418.1) - CDCR353972 from Creative Biomart
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Human ZBP1 ORF Clone(NM_001160418.1) - CDCR353973 from Creative Biomart
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Human ZBP1 ORF Clone(NM_001160419.2) - CDCR353974 from Creative Biomart
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Human ZBP1 ORF Clone(NM_001160419.2) - CDCR353975 from Creative Biomart
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human ZBP1 ORF clone - CDCH102288 from Creative Biomart
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human ZBP1 ORF clone - CDCH102289 from Creative Biomart
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human ZBP1 ORF clone - CDCH102290 from Creative Biomart
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human ZBP1 ORF clone - CDCH102291 from Creative Biomart
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human ZBP1 ORF clone - CDCH102298 from Creative Biomart
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human ZBP1 ORF clone - CDCH102299 from Creative Biomart
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Human ZBP1 ORF Clone(NM_030776.2) - CDCL181572 from Creative Biomart
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Human ZBP1 ORF Clone(NM_001160419.2) - CDCR353974 from Creative biogene
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human ZBP1 ORF clone (NM_001160418.1) - CDCH102290 from Creative biogene
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human ZBP1 ORF clone (NM_001160417.1) - CDCH102298 from Creative biogene
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Human ZBP1 ORF Clone (BC028218) - CDCS408669 from Creative biogene
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Human ZBP1 ORF Clone (BC131706) - CDCS408670 from Creative biogene
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Human ZBP1 cDNA Clone(NM_001160417.1) - CDFH021457 from Creative biogene
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Human ZBP1 cDNA Clone(NM_001160418.1) - CDFH021458 from Creative biogene
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