| Gene Symbol |
RYK
|
| Entrez Gene |
6259
|
| Alt Symbol |
D3S3195, JTK5, JTK5A, RYK1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
receptor-like tyrosine kinase
|
| Other Description |
JTK5A protein tyrosine kinase|hydroxyaryl-protein kinase|tyrosine-protein kinase RYK
|
| Swissprots |
Q04696 P34925
|
| Accessions |
EAW79155 P34925 AB209405 BAD92642 BC021700 AAH21700 BC148614 AAI48615 BC153090 AAI53091 BQ003586 CN309980 S59184 AAB26341 X69970 CAA49591 X96588 CAA65406 XR_924160 NM_001005861 NP_001005861 NM_002958 NP_002949
|
| Function |
May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C- terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development. {ECO:0000269|PubMed:15454084}.
|
| Subcellular Location |
Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus. {ECO:0000250}.
|
| Tissue Specificity |
Observed in all the tissues examined.
|
![Western Blot: RYK Overexpression Lysate (Adult Normal) [NBP2-09101] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RYK.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/15903_RYK%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-09101-img0001.jpg)
![Western Blot: RYK Overexpression Lysate (Adult Normal) [NBP2-08054] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RYK.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/24454_RYK%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-08054-img0001.jpg)