RYK

Gene Symbol	RYK
Entrez Gene	6259
Alt Symbol	D3S3195, JTK5, JTK5A, RYK1
Species	Human
Gene Type	protein-coding
Description	receptor-like tyrosine kinase
Other Description	JTK5A protein tyrosine kinase|hydroxyaryl-protein kinase|tyrosine-protein kinase RYK
Swissprots	Q04696 P34925
Accessions	EAW79155 P34925 AB209405 BAD92642 BC021700 AAH21700 BC148614 AAI48615 BC153090 AAI53091 BQ003586 CN309980 S59184 AAB26341 X69970 CAA49591 X96588 CAA65406 XR_924160 NM_001005861 NP_001005861 NM_002958 NP_002949
Function	May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C- terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development. {ECO:0000269|PubMed:15454084}.
Subcellular Location	Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus. {ECO:0000250}.
Tissue Specificity	Observed in all the tissues examined.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RYK Gene cDNA Clone (full-length ORF Clone) - HG16075-G from Sino Biological Species Human Accession NM_001005861.2

Human RYK natural ORF mammalian expression plasmid, C-His tag - HG16075-CH from Sino Biological Species Human Accession NM_001005861.2

Human RYK natural ORF mammalian expression plasmid, N-Flag tag - HG16075-NF from Sino Biological Species Human Accession NM_001005861.2

Human RYK natural ORF mammalian expression plasmid, C-GFPSpark tag - HG16075-ACG from Sino Biological Species Human Accession NM_001005861.2

Human RYK Gene cDNA Clone (full-length ORF Clone), expression ready, N-HA-tagged - HG16075-NY from Sino Biological Species Human Accession NM_001005861.2

Human RYK natural ORF mammalian expression plasmid, C-OFPSpark tag - HG16075-ACR from Sino Biological Species Human Accession NM_001005861.2

Human RYK Gene cDNA Clone (full-length ORF Clone), expression ready, N-Myc-tagged - HG16075-NM from Sino Biological Species Human Accession NM_001005861.2

Human RYK Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG16075-UT from Sino Biological Species Human Accession NM_001005861.2

Human RYK natural ORF mammalian expression plasmid, C-HA tag - HG16075-CY from Sino Biological Species Human Accession NM_001005861.2

Human RYK Gene cDNA Clone (full-length ORF Clone), expression ready, C-Myc-tagged - HG16075-CM from Sino Biological Species Human Accession NM_001005861.2

Human RYK Gene cDNA Clone (full-length ORF Clone), expression ready, C-FLAG-tagged - HG16075-CF from Sino Biological Species Human Accession NM_001005861.2

Human RYK Gene cDNA Clone (full-length ORF Clone), expression ready, N-His-tagged - HG16075-NH from Sino Biological Species Human Accession NM_001005861.2

human RYK ORF clone (NM_001005861.2) - CDCH076534 from Creative biogene Species Human

human RYK ORF clone (NM_002958.3) - CDCH076536 from Creative biogene Species Human

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