RYK

Gene Symbol	RYK
Entrez Gene	6259
Alt Symbol	D3S3195, JTK5, JTK5A, RYK1
Species	Human
Gene Type	protein-coding
Description	receptor-like tyrosine kinase
Other Description	JTK5A protein tyrosine kinase|hydroxyaryl-protein kinase|tyrosine-protein kinase RYK
Swissprots	Q04696 P34925
Accessions	EAW79155 P34925 AB209405 BAD92642 BC021700 AAH21700 BC148614 AAI48615 BC153090 AAI53091 BQ003586 CN309980 S59184 AAB26341 X69970 CAA49591 X96588 CAA65406 XR_924160 NM_001005861 NP_001005861 NM_002958 NP_002949
Function	May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C- terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development. {ECO:0000269|PubMed:15454084}.
Subcellular Location	Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus. {ECO:0000250}.
Tissue Specificity	Observed in all the tissues examined.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RYK CRISPR/Cas9 KO Plasmid (h) - sc-402654 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

RYK HDR Plasmid (h) - sc-402654-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Mer Double Nickase Plasmid (h) - sc-402654-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RYK Double Nickase Plasmid (h2) - sc-402654-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Mer CRISPR Activation Plasmid (h) - sc-402654-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

RYK CRISPR Activation Plasmid (h2) - sc-402654-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Mer Lentiviral Activation Particles (h) - sc-402654-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RYK Lentiviral Activation Particles (h2) - sc-402654-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RYK siRNA (h) - sc-72221 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RYK shRNA Plasmid (h) - sc-72221-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RYK shRNA (h) Lentiviral Particles - sc-72221-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Ryk RNAi - H00006259-R08 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU153681 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK2037 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2038 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2039 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN18777 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18777 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

RYK siRNA (Human) - CRH4215 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Ryk RNAi - H00006259-R07 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

RYK - MBS8215348 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human Ryk (NM_002958.3) - SHH401020 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human RYK(NM_001005861.2) - SHR191522 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human RYK(NM_002958.3) - SHR191568 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human RYK(NM_001005861.2) - SHR191640 from Creative biogene Category siRNA Species Reactivities Human

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