| Gene Symbol |
IL11
|
| Entrez Gene |
3589
|
| Alt Symbol |
AGIF, IL-11
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interleukin 11
|
| Other Description |
adipogenesis inhibitory factor|interleukin-11|oprelvekin
|
| Swissprots |
Q96EB4 P20809 B4DQV5
|
| Accessions |
AAO13493 EAW72371 P20809 AK290572 BAF83261 AK298973 BAG61067 AK315294 BAG37700 BC012506 AAH12506 BF055151 M57765 AAA59132 X58377 CAA41266 NM_000641 NP_000632 NM_001267718 NP_001254647
|
| Function |
Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. {ECO:0000250|UniProtKB:P47873, ECO:0000269|PubMed:12919066, ECO:0000269|PubMed:2145578}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:1828438, ECO:0000269|PubMed:2145578}.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, Rheumatoid arthritis
|
![Western Blot: IL11 Overexpression Lysate (Adult Normal) [NBL1-11898] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for IL11.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1778_IL11%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11898-img0002.jpg)