IL11

Gene Symbol IL11
Entrez Gene 3589
Alt Symbol AGIF, IL-11
Species Human
Gene Type protein-coding
Description interleukin 11
Other Description adipogenesis inhibitory factor|interleukin-11|oprelvekin
Swissprots Q96EB4 P20809 B4DQV5
Accessions AAO13493 EAW72371 P20809 AK290572 BAF83261 AK298973 BAG61067 AK315294 BAG37700 BC012506 AAH12506 BF055151 M57765 AAA59132 X58377 CAA41266 NM_000641 NP_000632 NM_001267718 NP_001254647
Function Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. {ECO:0000250|UniProtKB:P47873, ECO:0000269|PubMed:12919066, ECO:0000269|PubMed:2145578}.
Subcellular Location Secreted {ECO:0000269|PubMed:1828438, ECO:0000269|PubMed:2145578}.
Top Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, Rheumatoid arthritis

IL-11 CRISPR/Cas9 KO Plasmid (h) - sc-401664 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-11 HDR Plasmid (h) - sc-401664-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-11 Double Nickase Plasmid (h) - sc-401664-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-11 Double Nickase Plasmid (h2) - sc-401664-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-11 CRISPR Activation Plasmid (h) - sc-401664-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-11 CRISPR Activation Plasmid (h2) - sc-401664-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-11 Lentiviral Activation Particles (h) - sc-401664-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-11 Lentiviral Activation Particles (h2) - sc-401664-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-11 siRNA (h) - sc-39636 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IL-11 shRNA Plasmid (h) - sc-39636-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IL-11 shRNA (h) Lentiviral Particles - sc-39636-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN10563 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10563 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09826 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09826

IL11 siRNA (Human) - CRH2399 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IL-11 RNAi - H00003589-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

IL11 - MBS8230263 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human IL11 (NM_000641.3) - SHH318129 from Creative biogene

Category siRNA
Species Reactivities Human

Human IL11 siRNA - orb262901 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IL11 shRNA Plasmid (Human) - CHH2399 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

IL11 miRNA 3'UTR clone - MiUTR4H-TG04481 from Creative biogene

Species Reactivities Human
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