IL11

Gene Symbol	IL11
Entrez Gene	3589
Alt Symbol	AGIF, IL-11
Species	Human
Gene Type	protein-coding
Description	interleukin 11
Other Description	adipogenesis inhibitory factor|interleukin-11|oprelvekin
Swissprots	Q96EB4 P20809 B4DQV5
Accessions	AAO13493 EAW72371 P20809 AK290572 BAF83261 AK298973 BAG61067 AK315294 BAG37700 BC012506 AAH12506 BF055151 M57765 AAA59132 X58377 CAA41266 NM_000641 NP_000632 NM_001267718 NP_001254647
Function	Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. {ECO:0000250|UniProtKB:P47873, ECO:0000269|PubMed:12919066, ECO:0000269|PubMed:2145578}.
Subcellular Location	Secreted {ECO:0000269|PubMed:1828438, ECO:0000269|PubMed:2145578}.
Top Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, Rheumatoid arthritis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IL11 Gene cDNA Clone - orb143719 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human-IL11-cDNA-Clone - DC03427 from Abgent, a WuXi AppTec company Prices $270.00 Sizes 10 µg Species Human

IL11 - MBS1276505 from MyBioSource Species Human Accession BC012506

Human IL-11 / interleukin 11 Gene ORF cDNA clone in cloning vector - HG12225-G from Sino Biological Species Human

Human IL-11 / interleukin 11 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG12225-NF from Sino Biological Species Human

Human IL-11 / interleukin 11 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG12225-NM from Sino Biological Species Human

Human IL-11 / interleukin 11 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG12225-CF from Sino Biological Species Human

Human IL11 Gene cDNA Clone (full-length ORF Clone), expression ready, C-Myc-tagged - HG12225-CM from Sino Biological Species Human Accession BC012506

Human IL-11 / interleukin 11 Gene ORF cDNA clone expression plasmid, C-HA tag - HG12225-CY from Sino Biological Species Human

Human IL-11 / interleukin 11 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG12225-ACG from Sino Biological Species Human

Human IL-11 / interleukin 11 Gene ORF cDNA clone expression plasmid, N-His tag - HG12225-NH from Sino Biological Species Human

Human IL-11 / interleukin 11 Gene ORF cDNA clone expression plasmid, N-HA tag - HG12225-NY from Sino Biological Species Human

Human IL-11 / interleukin 11 Gene ORF cDNA clone expression plasmid - HG12225-UT from Sino Biological Species Human

Human IL-11 / interleukin 11 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG12225-ACR from Sino Biological Species Human

Human IL-11 / interleukin 11 Gene ORF cDNA clone expression plasmid, C-His tag - HG12225-CH from Sino Biological Species Human

Human IL11 ORF Clone (BC012506) - CDCS405814 from Creative biogene Species Human Accession P20809

Human IL11 ORF clone (BC012506) - CDCB160169 from Creative biogene Species Human

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