IL11

Gene Symbol	IL11
Entrez Gene	3589
Alt Symbol	AGIF, IL-11
Species	Human
Gene Type	protein-coding
Description	interleukin 11
Other Description	adipogenesis inhibitory factor|interleukin-11|oprelvekin
Swissprots	Q96EB4 P20809 B4DQV5
Accessions	AAO13493 EAW72371 P20809 AK290572 BAF83261 AK298973 BAG61067 AK315294 BAG37700 BC012506 AAH12506 BF055151 M57765 AAA59132 X58377 CAA41266 NM_000641 NP_000632 NM_001267718 NP_001254647
Function	Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. {ECO:0000250|UniProtKB:P47873, ECO:0000269|PubMed:12919066, ECO:0000269|PubMed:2145578}.
Subcellular Location	Secreted {ECO:0000269|PubMed:1828438, ECO:0000269|PubMed:2145578}.
Top Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, Rheumatoid arthritis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human IL11 full length protein - ab151817 from Abcam Category Protein Prices $192.00 Sizes 10 µg Source Pichia pastoris Species Human

Active human IL11 full length protein - ab73620 from Abcam Category Protein Prices $257.00 Sizes 10 µg Source E. coli Species Human

Active IL11 full length protein - ab9553 from Abcam Category Protein Prices $110.00, $257.00 Sizes 2 µg, 10 µg Source E. coli

Active mouse IL11 full length protein - ab69654 from Abcam Category Protein Prices $110.00, $257.00 Sizes 2 µg, 10 µg Source E. coli Species Mouse

Active mouse IL11 full length protein - ab200279 from Abcam Category Protein Prices $101.00 Sizes 2 µg Source E. coli Species Mouse

Active mouse IL11 full length protein - ab187212 from Abcam Category Protein Prices $291.00 Sizes 10 µg Source E. coli Species Mouse

Active mouse IL11 full length protein - ab192168 from Abcam Category Protein Prices $192.00 Sizes 10 µg Source E. coli Species Mouse

Human IL11 full length protein - ab193883 from Abcam Category Protein Source Mammalian Species Human

Human IL11 peptide - ab90835 from Abcam Category Peptide

Human IL-11 Protein - NBP2-35017 from Novus Biologicals Category Protein Prices $75.00 Sizes 2 µg Source Escherichia coli. Species Human

IL-11 Partial Recombinant Protein - H00003589-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

IL-11 Recombinant Protein - H00003589-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

IL-11 Recombinant Protein - P4405 from Novus Biologicals Category Protein Prices $549.00 Sizes 10 µg Species Human

IL-11 Protein - NBP1-99824 from Novus Biologicals Category Protein Prices $299.00 Sizes 10 µg Species Human

IL-11 Protein - NBP1-43216 from Novus Biologicals Category Protein Prices $299.00 Sizes 5 µg

IL-11 Protein - NBP2-26543 from Novus Biologicals Category Protein Prices $539.00 Sizes 10 µg

IL11 protein - GTX29553 from GeneTex Category Protein Prices $299.00 Sizes 10 μg Species Human

IL11 recombinant protein - GTX65142 from GeneTex Category Protein Prices $249.00 Sizes 10 μg Source E. coli Species Human

IL11 Recombinant Protein (Active) - GTX48418-PRO from GeneTex Category Protein Prices $299.00 Sizes 10 μg Source E. coli Species Human

Recombinant Human IL-11 - 218-IL-005 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Pro22-Leu199

Recombinant Human IL-11 - 218-IL-025 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Pro22-Leu199

Recombinant Human IL-11, CF - 218-IL-005/CF from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Pro22-Leu199

Recombinant Human IL-11, CF - 218-IL-025/CF from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Pro22-Leu199

Recombinant Human IL-11, ACFP Protein - ACFP218 from R&D Systems Category Protein Prices $999.00 Sizes 50 µg Source Spodoptera frugiperda , Sf 9 (baculovirus)-derived Pro22-Leu199 Produced in an animal component free process (ACFP). Species Human

Recombinant Human IL-11 GMP, CF - 218-GMP-01M from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 9(baculovirus)-derived

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