| Gene Symbol |
FANCL
|
| Entrez Gene |
55120
|
| Alt Symbol |
FAAP43, PHF9, POG
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Fanconi anemia, complementation group L
|
| Other Description |
E3 ubiquitin-protein ligase FANCL|PHD finger protein 9|fanconi anemia group L protein|fanconi anemia-associated polypeptide of 43 kDa
|
| Swissprots |
Q6GU60 Q9NW38
|
| Accessions |
AAY15020 EAX00056 EAX00057 EAX00058 EAX00059 EAX00060 EAX00061 Q9NW38 AK001197 BAA91548 AK225147 AK297736 BAG60086 AK309671 AL036481 BC009042 AAH09042 BC037570 BC041627 BC054517 AAH54517 BQ574618 DB032206 XM_005264395 XP_005264452 XM_005264397 XP_005264454 XM_011532939 XP_011531241 XM_011532940 XP_011531242 XM_011532941 XP_011531243 XM_011532942 XP_011531244 XM_011532943 XP_011531245 XM_011532944 XP_011531246 XM_011532945 XP_011531247 XR_939692 NM_001114636 NP_001108108 NM_018062 NP_060532
|
| Function |
Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth. {ECO:0000269|PubMed:12973351, ECO:0000269|PubMed:16916645, ECO:0000269|PubMed:17938197, ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:19589784}.
|
| Subcellular Location |
Cytoplasm. Nucleus.
|
| Top Pathways |
Ubiquitin mediated proteolysis, Fanconi anemia pathway
|
![Western Blot: FANCL Overexpression Lysate (Adult Normal) [NBL1-10590] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FANCL.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1636_FANCL%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10590-img0002.jpg)