FANCL

Gene Symbol FANCL
Entrez Gene 55120
Alt Symbol FAAP43, PHF9, POG
Species Human
Gene Type protein-coding
Description Fanconi anemia, complementation group L
Other Description E3 ubiquitin-protein ligase FANCL|PHD finger protein 9|fanconi anemia group L protein|fanconi anemia-associated polypeptide of 43 kDa
Swissprots Q6GU60 Q9NW38
Accessions AAY15020 EAX00056 EAX00057 EAX00058 EAX00059 EAX00060 EAX00061 Q9NW38 AK001197 BAA91548 AK225147 AK297736 BAG60086 AK309671 AL036481 BC009042 AAH09042 BC037570 BC041627 BC054517 AAH54517 BQ574618 DB032206 XM_005264395 XP_005264452 XM_005264397 XP_005264454 XM_011532939 XP_011531241 XM_011532940 XP_011531242 XM_011532941 XP_011531243 XM_011532942 XP_011531244 XM_011532943 XP_011531245 XM_011532944 XP_011531246 XM_011532945 XP_011531247 XR_939692 NM_001114636 NP_001108108 NM_018062 NP_060532
Function Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth. {ECO:0000269|PubMed:12973351, ECO:0000269|PubMed:16916645, ECO:0000269|PubMed:17938197, ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:19589784}.
Subcellular Location Cytoplasm. Nucleus.
Top Pathways Ubiquitin mediated proteolysis, Fanconi anemia pathway

FANCL CRISPR/Cas9 KO Plasmid (h) - sc-403812 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FANCL HDR Plasmid (h) - sc-403812-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FANCL Double Nickase Plasmid (h) - sc-403812-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FANCL Double Nickase Plasmid (h2) - sc-403812-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FANCL CRISPR Activation Plasmid (h) - sc-403812-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FANCL CRISPR Activation Plasmid (h2) - sc-403812-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FANCL Lentiviral Activation Particles (h) - sc-403812-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FANCL Lentiviral Activation Particles (h2) - sc-403812-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FANCL siRNA (h) - sc-45661 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FANCL shRNA Plasmid (h) - sc-45661-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FANCL shRNA (h) Lentiviral Particles - sc-45661-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU143771 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8477 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8477 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

FANCL siRNA (Human) - CRJ0484 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FANCL - MBS8208564 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FANCL (NM_018062.3) - SHH292345 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human FANCL(NM_018062.3) - SHH049079 from Creative biogene

Category siRNA
Species Reactivities Human

Human FANCL siRNA - orb270985 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FANCL shRNA Plasmid (Human) - CHJ0484 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FANCL miRNA 3'UTR clone - MiUTR1H-03511 from Creative biogene

Species Reactivities Human

FANCL miRNA 3'UTR clone - MiUTR3H-09746 from Creative biogene

Species Reactivities Human
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