SMURF2

Gene Symbol	SMURF2
Entrez Gene	64750
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	SMAD specific E3 ubiquitin protein ligase 2
Other Description	E3 ubiquitin ligase SMURF2|E3 ubiquitin-protein ligase SMURF2|SMAD ubiquitination regulatory factor 2|SMAD-specific E3 ubiquitin-protein ligase 2|hSMURF2
Swissprots	Q52LL1 Q9H260 Q9HAU4
Accessions	CCQ43691 EAW94193 EAW94194 EAW94195 Q9HAU4 AF301463 AAG25641 AF310676 AAG45422 AK002019 AY014180 AAG50421 BC009527 AAH09527 BC034789 BC051283 BC093876 AAH93876 BC111945 AAI11946 BP363931 CB267500 CN310238 CN370887 CR936721 XM_005257585 XP_005257642 XM_011525128 XP_011523430 NM_022739 NP_073576
Function	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level. {ECO:0000269|PubMed:11389444, ECO:0000269|PubMed:12717440}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12717440}. Cytoplasm {ECO:0000269|PubMed:12717440}. Cell membrane {ECO:0000269|PubMed:12717440}. Membrane raft {ECO:0000269|PubMed:12717440}. Note=Cytoplasmic in the presence of SMAD7. Colocalizes with CAV1, SMAD7 and TGF-beta receptor in membrane rafts.
Tissue Specificity	Widely expressed.
Top Pathways	Ubiquitin mediated proteolysis, TGF-beta signaling pathway, Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SMAD specific E3 ubiquitin protein ligase 2, ELISA Kit - MBS9336626 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/ml Range 1.56 ng/ml - 50 ng/ml

ELISA Kit for Smad Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) - SEL082Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.27ng/mL. Range 0.781-50ng/mL The standard curve concentrations used for the ELISA’s were 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL, 0.781ng/mL

Human SMURF2 ELISA Kit - E035450 from Biobool Category ELISA Kit

E3 Ubiquitin-Protein Ligase SMURF2 (SMURF2), ELISA Kit - MBS9395522 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SMURF2 (SMURF2), ELISA Kit - MBS9395530 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SMURF2 (SMURF2), ELISA Kit - MBS9395515 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SMURF2 (SMURF2), ELISA Kit - MBS9395518 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SMURF2 (SMURF2), ELISA Kit - MBS9395516 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SMURF2 (SMURF2), ELISA Kit - MBS9395517 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SMURF2 (SMURF2), ELISA Kit - MBS9395521 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SMURF2 (SMURF2), ELISA Kit - MBS9395526 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SMURF2 (SMURF2), ELISA Kit - MBS9395519 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SMURF2 (SMURF2), ELISA Kit - MBS9395523 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SMURF2 (SMURF2), ELISA Kit - MBS9395525 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SMURF2 (SMURF2), ELISA Kit - MBS9395524 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SMURF2 (SMURF2), ELISA Kit - MBS9395520 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SMURF2 (SMURF2), ELISA Kit - MBS9395527 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SMURF2 (SMURF2), ELISA Kit - MBS9395528 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SMURF2 (SMURF2), ELISA Kit - MBS9395529 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SMURF2 (SMURF2), ELISA Kit - MBS9395531 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SMURF2 (SMURF2), ELISA Kit - MBS9395532 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SMURF2 (SMURF2), ELISA Kit - MBS9395533 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Smad Specific E3 Ubiquitin Protein Ligase 2, ELISA Kit - MBS2031919 from MyBioSource Category ELISA Kit Prices $435.00, $650.00, $895.00, $3,690.00, $6,650.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.27ng/mL. Range 0.78 -50ng/mL. The standard curve concentrations used for the ELISA's were 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.12ng/mL, 1.56ng/mL, 0.78ng/mL.

E3 Ubiquitin-Protein Ligase SMURF2 (SMURF2), ELISA Kit - MBS9395534 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rat SMURF2 ELISA Kit (Sandwich ELISA) - LS-F39097 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.27 Range 0.781-50 ng/ml

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