| Gene Symbol |
SMURF2
|
| Entrez Gene |
64750
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SMAD specific E3 ubiquitin protein ligase 2
|
| Other Description |
E3 ubiquitin ligase SMURF2|E3 ubiquitin-protein ligase SMURF2|SMAD ubiquitination regulatory factor 2|SMAD-specific E3 ubiquitin-protein ligase 2|hSMURF2
|
| Swissprots |
Q52LL1 Q9H260 Q9HAU4
|
| Accessions |
CCQ43691 EAW94193 EAW94194 EAW94195 Q9HAU4 AF301463 AAG25641 AF310676 AAG45422 AK002019 AY014180 AAG50421 BC009527 AAH09527 BC034789 BC051283 BC093876 AAH93876 BC111945 AAI11946 BP363931 CB267500 CN310238 CN370887 CR936721 XM_005257585 XP_005257642 XM_011525128 XP_011523430 NM_022739 NP_073576
|
| Function |
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level. {ECO:0000269|PubMed:11389444, ECO:0000269|PubMed:12717440}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12717440}. Cytoplasm {ECO:0000269|PubMed:12717440}. Cell membrane {ECO:0000269|PubMed:12717440}. Membrane raft {ECO:0000269|PubMed:12717440}. Note=Cytoplasmic in the presence of SMAD7. Colocalizes with CAV1, SMAD7 and TGF-beta receptor in membrane rafts.
|
| Tissue Specificity |
Widely expressed.
|
| Top Pathways |
Ubiquitin mediated proteolysis, TGF-beta signaling pathway, Endocytosis
|
![Western Blot: SMURF 2 Overexpression Lysate (Adult Normal) [NBL1-16260] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SMURF 2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1392_SMURF%25202%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16260-img0002.jpg)