SMURF2

Gene Symbol SMURF2
Entrez Gene 64750
Alt Symbol -
Species Human
Gene Type protein-coding
Description SMAD specific E3 ubiquitin protein ligase 2
Other Description E3 ubiquitin ligase SMURF2|E3 ubiquitin-protein ligase SMURF2|SMAD ubiquitination regulatory factor 2|SMAD-specific E3 ubiquitin-protein ligase 2|hSMURF2
Swissprots Q52LL1 Q9H260 Q9HAU4
Accessions CCQ43691 EAW94193 EAW94194 EAW94195 Q9HAU4 AF301463 AAG25641 AF310676 AAG45422 AK002019 AY014180 AAG50421 BC009527 AAH09527 BC034789 BC051283 BC093876 AAH93876 BC111945 AAI11946 BP363931 CB267500 CN310238 CN370887 CR936721 XM_005257585 XP_005257642 XM_011525128 XP_011523430 NM_022739 NP_073576
Function E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level. {ECO:0000269|PubMed:11389444, ECO:0000269|PubMed:12717440}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12717440}. Cytoplasm {ECO:0000269|PubMed:12717440}. Cell membrane {ECO:0000269|PubMed:12717440}. Membrane raft {ECO:0000269|PubMed:12717440}. Note=Cytoplasmic in the presence of SMAD7. Colocalizes with CAV1, SMAD7 and TGF-beta receptor in membrane rafts.
Tissue Specificity Widely expressed.
Top Pathways Ubiquitin mediated proteolysis, TGF-beta signaling pathway, Endocytosis

Smurf2 CRISPR/Cas9 KO Plasmid (h) - sc-401431 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smurf2 HDR Plasmid (h) - sc-401431-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smurf2 Double Nickase Plasmid (h) - sc-401431-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smurf2 Double Nickase Plasmid (h2) - sc-401431-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smurf2 CRISPR Activation Plasmid (h) - sc-401431-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smurf2 CRISPR Activation Plasmid (h2) - sc-401431-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smurf2 Lentiviral Activation Particles (h) - sc-401431-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smurf2 Lentiviral Activation Particles (h2) - sc-401431-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smurf2 siRNA (h) - sc-41675 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Smurf2 shRNA Plasmid (h) - sc-41675-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Smurf2 shRNA (h) Lentiviral Particles - sc-41675-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU104801 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19814 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19814 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08685 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08685

SMURF2 siRNA (Human) - CRJ2062 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SMURF2 - MBS8212816 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SMURF2 (NM_022739.3) - SHH413752 from Creative biogene

Category siRNA
Species Reactivities Human

SMURF2 shRNA Plasmid (Human) - CHJ2062 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SMURF2 miRNA 3'UTR clone - MiUTR1H-09675 from Creative biogene

Species Reactivities Human
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