SMURF2

Gene Symbol	SMURF2
Entrez Gene	64750
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	SMAD specific E3 ubiquitin protein ligase 2
Other Description	E3 ubiquitin ligase SMURF2|E3 ubiquitin-protein ligase SMURF2|SMAD ubiquitination regulatory factor 2|SMAD-specific E3 ubiquitin-protein ligase 2|hSMURF2
Swissprots	Q52LL1 Q9H260 Q9HAU4
Accessions	CCQ43691 EAW94193 EAW94194 EAW94195 Q9HAU4 AF301463 AAG25641 AF310676 AAG45422 AK002019 AY014180 AAG50421 BC009527 AAH09527 BC034789 BC051283 BC093876 AAH93876 BC111945 AAI11946 BP363931 CB267500 CN310238 CN370887 CR936721 XM_005257585 XP_005257642 XM_011525128 XP_011523430 NM_022739 NP_073576
Function	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level. {ECO:0000269|PubMed:11389444, ECO:0000269|PubMed:12717440}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12717440}. Cytoplasm {ECO:0000269|PubMed:12717440}. Cell membrane {ECO:0000269|PubMed:12717440}. Membrane raft {ECO:0000269|PubMed:12717440}. Note=Cytoplasmic in the presence of SMAD7. Colocalizes with CAV1, SMAD7 and TGF-beta receptor in membrane rafts.
Tissue Specificity	Widely expressed.
Top Pathways	Ubiquitin mediated proteolysis, TGF-beta signaling pathway, Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SMURF2 cDNA clone(NM_022739.3) - CDFG003895 from Creative Biomart Species Human Accession NM_022739.3

Human SMURF2 ORF clone(NM_022739.3) - CDCL186246 from Creative Biomart Species Human Accession NM_022739.3

Human SMURF2 ORF Clone(NM_022739.3) - CDCR308053 from Creative Biomart Species Human Accession NM_022739.3

Human SMURF2 ORF Clone(NM_022739.3) - CDCR308054 from Creative Biomart Species Human Accession NM_022739.3

Human SMURF2 ORF Clone(NM_022739.3) - CDCR308055 from Creative Biomart Species Human Accession NM_022739.3

Human SMURF2 ORF clone(NM_022739.3) - CDCH401474 from Creative Biomart Species Human Accession NM_022739.3

Human SMURF2 ORF Clone(NM_022739.3) - CDCL176458 from Creative Biomart Species Human Accession NM_022739.3

human SMURF2 ORF clone - CDCH083808 from Creative Biomart Species Human Accession NM_022739

human SMURF2 ORF clone - CDCH083809 from Creative Biomart Species Human Accession NM_022739

Human SMURF2 Gene cDNA clone plasmid - HG11436-M from Sino Biological Species Human

Human SMURF2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11436-CY from Sino Biological Species Human

Human SMURF2 Gene ORF cDNA clone expression plasmid - HG11436-UT from Sino Biological Species Human

Human SMURF2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11436-ACG from Sino Biological Species Human

Human SMURF2 Gene ORF cDNA clone expression plasmid, N-His tag - HG11436-NH from Sino Biological Species Human

Human SMURF2 Gene ORF cDNA clone expression plasmid, C-His tag - HG11436-CH from Sino Biological Species Human

Human SMURF2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11436-NF from Sino Biological Species Human

Human SMURF2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11436-NM from Sino Biological Species Human

Human SMURF2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11436-CF from Sino Biological Species Human

Human SMURF2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11436-CM from Sino Biological Species Human

Human SMURF2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11436-ACR from Sino Biological Species Human

Human SMURF2 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged - HG11436-M-F from Sino Biological Species Human Accession NM_022739.3

Human SMURF2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11436-NY from Sino Biological Species Human

Human SMURF2 ORF clone(NM_022739.3) - CDCL186246 from Creative biogene Species Human

Human SMURF2 cDNA Clone(NM_022739.3) - CDFG003895 from Creative biogene Species Human

Human SMURF2 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11436-ANG from Sino Biological Species Human

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