SMURF2

Gene Symbol	SMURF2
Entrez Gene	64750
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	SMAD specific E3 ubiquitin protein ligase 2
Other Description	E3 ubiquitin ligase SMURF2|E3 ubiquitin-protein ligase SMURF2|SMAD ubiquitination regulatory factor 2|SMAD-specific E3 ubiquitin-protein ligase 2|hSMURF2
Swissprots	Q52LL1 Q9H260 Q9HAU4
Accessions	CCQ43691 EAW94193 EAW94194 EAW94195 Q9HAU4 AF301463 AAG25641 AF310676 AAG45422 AK002019 AY014180 AAG50421 BC009527 AAH09527 BC034789 BC051283 BC093876 AAH93876 BC111945 AAI11946 BP363931 CB267500 CN310238 CN370887 CR936721 XM_005257585 XP_005257642 XM_011525128 XP_011523430 NM_022739 NP_073576
Function	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level. {ECO:0000269|PubMed:11389444, ECO:0000269|PubMed:12717440}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12717440}. Cytoplasm {ECO:0000269|PubMed:12717440}. Cell membrane {ECO:0000269|PubMed:12717440}. Membrane raft {ECO:0000269|PubMed:12717440}. Note=Cytoplasmic in the presence of SMAD7. Colocalizes with CAV1, SMAD7 and TGF-beta receptor in membrane rafts.
Tissue Specificity	Widely expressed.
Top Pathways	Ubiquitin mediated proteolysis, TGF-beta signaling pathway, Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human SMURF 2 protein fragment - ab95930 from Abcam Category Protein Prices $396.00 Sizes 20 µg Source Baculovirus Species Human

SMURF 2 peptide - ab109647 from Abcam Category Peptide

SMURF2 Antibody Blocking Peptide - LS-E6854 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SMURF2 Antibody Blocking Peptide - LS-E6855 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SMURF2 Peptide - P0870 from Novus Biologicals Category Peptide Species Human

SMURF2 Peptide - P0869 from Novus Biologicals Category Peptide Species Human

SMURF2-Antibody-C-term-Blocking-Peptide - BP2105b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SMURF2-Antibody-N-term-Blocking-Peptide - BP2105a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human SMURF2 protein - orb246639 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human SMURF2 protein - orb246880 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

SMURF2 Peptide - 7773P from ProSci Category Peptide Species Human

SMURF2 fusion protein - Ag12666 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, T-HIS Species Human

SMURF2, Active Human Recombinant Protein - GWB-5581F8 from Genway Biotech Category Protein Prices $485.00 Sizes 20 µg Species Human

Recombinant Human SMURF2, FLAG-tagged - SMURF2-468H from Creative Biomart Category Protein Source Sf9 .

Recombinant Human SMURF2, FLAG-tagged - SMURF2-31425TH from Creative Biomart Category Protein Source Baculovirus

Recombinant Human SMURF2, His-tagged - SMURF2-2827H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human SMURF2, GST-tagged - SMURF2-138H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human E3 ubiquitin-protein ligase SMURF2(SMURF2) - CSB-YP872532HU CSB-BP872532HU CSB-MP872532HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant Human E3 ubiquitin-protein ligase SMURF2(SMURF2) - CSB-EP872532HU from Cusabio Category Protein Source Yeast Species Human

SMURF2 - TP310866 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

SMURF2 Peptide, Human - M34GP14784H from Creative Peptides Category Peptide Source Synthetic. Species Human

SMURF2 Recombinant Protein (OPCA02489) - OPCA02489 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

SMURF2 Recombinant Protein (OPCA03071) - OPCA03071 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Recombinant human E3 ubiquitin-protein ligase SMURF2 - AP71554 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

Recombinant Homo sapiens E3 ubiquitin-protein ligase SMURF2 - AP73129 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source Yeast

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