SMURF2

Gene Symbol SMURF2
Entrez Gene 64750
Alt Symbol -
Species Human
Gene Type protein-coding
Description SMAD specific E3 ubiquitin protein ligase 2
Other Description E3 ubiquitin ligase SMURF2|E3 ubiquitin-protein ligase SMURF2|SMAD ubiquitination regulatory factor 2|SMAD-specific E3 ubiquitin-protein ligase 2|hSMURF2
Swissprots Q52LL1 Q9H260 Q9HAU4
Accessions CCQ43691 EAW94193 EAW94194 EAW94195 Q9HAU4 AF301463 AAG25641 AF310676 AAG45422 AK002019 AY014180 AAG50421 BC009527 AAH09527 BC034789 BC051283 BC093876 AAH93876 BC111945 AAI11946 BP363931 CB267500 CN310238 CN370887 CR936721 XM_005257585 XP_005257642 XM_011525128 XP_011523430 NM_022739 NP_073576
Function E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level. {ECO:0000269|PubMed:11389444, ECO:0000269|PubMed:12717440}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12717440}. Cytoplasm {ECO:0000269|PubMed:12717440}. Cell membrane {ECO:0000269|PubMed:12717440}. Membrane raft {ECO:0000269|PubMed:12717440}. Note=Cytoplasmic in the presence of SMAD7. Colocalizes with CAV1, SMAD7 and TGF-beta receptor in membrane rafts.
Tissue Specificity Widely expressed.
Top Pathways Ubiquitin mediated proteolysis, TGF-beta signaling pathway, Endocytosis

Smurf2 (D8B8) Rabbit mAb - 12024 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D8B8
Western blot analysis of extracts from U-2 OS and ACHN cells using Smurf2 (D8B8) Rabbit mAb.

Smurf2 (D-5) - sc-393848 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Smurf2 (D-5): sc-393848. Western blot analysis of Smurf2 expression in WI-38 (A), U-2 OS (B) and DU 145 (C) whole cell lysates.

Smurf2 (H-50) - sc-25511 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Smurf2 (H-50): sc-25511. Immunoperoxidase staining of formalin fixed, paraffin-embedded human skin tissue showing cytoplasmic staining of keratinocytes, fibroblasts, Langerhans cells and melanocytes.

Smurf2 (P-18) - sc-14911 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Smurf2 (P-18): sc-14911. Western blot analysis of Smurf2 expression in mouse kidney tissue extract.

Smurf2 (E-16) - sc-14910 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Smurf2 (Y-21) - sc-130878 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Smurf2 (Y-21): sc-130878. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytoplasmic and membrane localization.

Anti-SMURF 2 antibody - ab38543 from Abcam

Prices $379.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SMURF 2 antibody (ab38543) at 1/100 dilution + Mouse brain tissue lysate

Anti-SMURF 2 antibody - ab17919 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab17919 staining SMURF 2 in Xenopus Laevis cultured retinal ganglion cell growth cone tissue by Immunocytochemistry/ Immunoflourescence. Cells were PFA-fixed and permeabilized in 0.1% Triton X-100 prior to blocking in 5% serum for 1 hour at 21°C. The primary antibody was diluted 1/250 in PBS and incubated with the sample for 16 hours at 4°C. The secondary antibody was Alexa Fluor® 488-conjugated Goat anti-Rabbit polyclonal, diluted 1/1000.

Anti-SMURF 2 antibody [EP629Y3] - ab53316 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP629Y3
Anti-SMURF 2 antibody [EP629Y3] (ab53316) at 1/500 dilution + SH-SY-5Y cell lysate at 10 µgSecondaryGoat anti-rabbit HRP labeled at 1/2000 dilution

Anti-SMURF 2 antibody - N-terminal - ab191697 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SMURF 2 antibody - N-terminal (ab191697) at 1 µg/ml + C2C12 cell lysate at 15 µg

Anti-SMURF2 Antibody (aa161-174) - LS-C10240 from LifeSpan Bioscience

Prices $475.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMURF2 Antibody (aa2-15) - LS-C132145 from LifeSpan Bioscience

Prices $590.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SMURF2 Antibody (N-Terminus) - LS-C203282 from LifeSpan Bioscience

Prices $245.00
Sizes 40 µg
Host Rabbit
Clonality Polyclonal

Anti-SMURF2 Antibody (aa714-743, AP) - LS-C217639 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMURF2 Antibody (aa714-743, APC) - LS-C217641 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMURF2 Antibody (aa714-743, Biotin) - LS-C217642 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMURF2 Antibody (aa714-743, FITC) - LS-C217643 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMURF2 Antibody (aa714-743, PE) - LS-C217644 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMURF2 Antibody (aa714-743, Azide-free, HRP) - LS-C217645 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMURF2 Antibody (N-Terminus, APC) - LS-C220708 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMURF2 Antibody (N-Terminus, AP) - LS-C220707 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMURF2 Antibody (N-Terminus, Biotin) - LS-C220711 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMURF2 Antibody (N-Terminus, Azide-free, HRP) - LS-C220712 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMURF2 Antibody (N-Terminus, FITC) - LS-C220713 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMURF2 Antibody (N-Terminus, PE) - LS-C220714 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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