NUDT1

Gene Symbol	NUDT1
Entrez Gene	4521
Alt Symbol	MTH1
Species	Human
Gene Type	protein-coding
Description	nudix (nucleoside diphosphate linked moiety X)-type motif 1
Other Description	2-hydroxy-dATP diphosphatase|7,8-dihydro-8-oxoguanine triphosphatase|8-oxo-7,8-dihydrodeoxyguanosine triphosphatase|8-oxo-7,8-dihydroguanosine triphosphatase|8-oxo-dGTPase|mutT human homolog 1|nucleoside diphosphate-linked moiety X motif 1|nucleoside diphosphate-linked moiety X-type motif 1|nudix motif 1
Swissprots	Q7Z7N6 P36639 Q9UBM0 Q6P0Y6 A4D205 Q9UBM9 Q6LES7 Q8IV95
Accessions	ABB02181 BAA07601 EAL23948 EAL23949 EAW87225 EAW87226 EAW87227 EAW87228 EAW87229 EAW87230 EAW87231 EAW87232 P36639 AB025233 BAA83791 AB025234 BAA83792 AB025235 BAA83793 AB025236 BAA83794 AB025237 BAA83795 AB025238 BAA83796 AB025239 BAA83797 AB025240 BAA83798 AB025241 BAA83799 AB025242 BAA83800 AK026631 BC014618 AAH14618 BC022818 BC040144 AAH40144 BC051375 AAH51375 BC065367 AAH65367 BM927392 CR407655 CAG28583 D16581 BAA04013 NM_002452 NP_002443 NM_198948 NP_945186 NM_198949 NP_945187 NM_198950 NP_945188 NM_198952 NP_945190 NM_198953 NP_945191 NM_198954 NP_945192
Function	Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. {ECO:0000269|PubMed:10373420, ECO:0000269|PubMed:10608900, ECO:0000269|PubMed:11139615, ECO:0000269|PubMed:12857738, ECO:0000269|PubMed:22556419}.
Subcellular Location	Isoform p18: Cytoplasm. Mitochondrion matrix. Nucleus. Note=Mostly present in cytoplasm. Variant Met-124 has decreased efficiency in translocation to mitochondria.
Tissue Specificity	Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes. {ECO:0000269|PubMed:9211940}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NUDT1 / MTH1 ELISA Kit (Sandwich ELISA) - LS-F10690 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.78 Range 0.78-50 ng/ml

7,8-dihydro-8-oxoguanine triphosphatase, NUDT1, Human, ELISA Kit - E3104h from ARP American Research Products Category ELISA Kit Prices $660.00 Sizes 96 t Range 0.78-50 ng/mL

NUDT1 (Human) IP-WB Antibody Pair - H00004521-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

NUDT1 (Human) Matched Antibody Pair - H00004521-AP11 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Rat NUDT1 / MTH1 ELISA Kit (Custom ELISA) - LS-F19832 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.78-50 ng/ml

Mouse NUDT1 / MTH1 ELISA Kit (Sandwich ELISA) - LS-F19833 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.78 Range 0.78-50 ng/ml

Human 7,8-dihydro-8-oxoguanine triphosphatase ELISA Kit - abx251602 from Abbexa Category ELISA Kit Range 0.78 ng/ml - 50 ng/ml

Human 7,8-dihydro-8-oxoguanine triphosphatase ELISA Kit - EKE54391 from Biomatik Category ELISA Kit Prices $759.00, $3,225.75, $6,072.00 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.23 ng/mL Range 0.78-50 ng/mL

NUDT1 - EKH4510 from Nordic BioSite Sensitivity 0.469ng/ml Range 0.78-50ng/ml

NUDT1 ELISA Kit (Human) (OKEH01689) - OKEH01689 from Aviva Systems Biology Category ELISA Kit Prices $450.00 Sizes 96 wells Sensitivity < 0.23 ng/mL Range 0.78 - 50 ng/mL

Human NUDT1 ELISA Kit - E042198 from Biobool Category ELISA Kit Sensitivity <0.469ng/ml

Human 7,8-dihydro-8-oxoguanine triphosphatase ELISA Kit - EK4571 from Signalway Antibody Category ELISA Kit Prices $659.00 Sizes 1x96t Range 78-5000 pg/mL

anti-MTH1 antibody - ARG56305 from Arigo Biolaboratories Category ELISA Kit

anti-MTH1 antibody [3B3] - ARG57149 from Arigo Biolaboratories Category ELISA Kit

7,8-Dihydro-8-Oxoguanine Triphosphatase (NUDT1), ELISA Kit - MBS9390376 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

7,8-Dihydro-8-Oxoguanine Triphosphatase (NUDT1), ELISA Kit - MBS9390384 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

7,8-Dihydro-8-Oxoguanine Triphosphatase (NUDT1), ELISA Kit - MBS9390372 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

7,8-Dihydro-8-Oxoguanine Triphosphatase (NUDT1), ELISA Kit - MBS9390375 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

7,8-Dihydro-8-Oxoguanine Triphosphatase (NUDT1), ELISA Kit - MBS9390377 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

7,8-Dihydro-8-Oxoguanine Triphosphatase (NUDT1), ELISA Kit - MBS9390378 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

7, 8-dihydro-8-oxoguanine triphosphatase, ELISA Kit - MBS9428397 from MyBioSource Category ELISA Kit Prices $605.00 Sizes 96 tests Sensitivity Less than 0.23ng/mL Range 0.78-50 ng/mL

7,8-dihydro-8-oxoguanine triphosphatase, ELISA Kit - MBS765888 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.469ng/ml Range 0.78-50ng/ml

7,8-dihydro-8-oxoguanine triphosphatase, ELISA Kit - MBS2887109 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.78-50 ng/mL

7,8-Dihydro-8-Oxoguanine Triphosphatase (NUDT1), ELISA Kit - MBS9390382 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human NUDT1 / MTH1 ELISA Kit (Sandwich ELISA) - LS-F32598 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.469 Range 0.78-50 ng/ml

Search more