NUDT1

Gene Symbol NUDT1
Entrez Gene 4521
Alt Symbol MTH1
Species Human
Gene Type protein-coding
Description nudix (nucleoside diphosphate linked moiety X)-type motif 1
Other Description 2-hydroxy-dATP diphosphatase|7,8-dihydro-8-oxoguanine triphosphatase|8-oxo-7,8-dihydrodeoxyguanosine triphosphatase|8-oxo-7,8-dihydroguanosine triphosphatase|8-oxo-dGTPase|mutT human homolog 1|nucleoside diphosphate-linked moiety X motif 1|nucleoside diphosphate-linked moiety X-type motif 1|nudix motif 1
Swissprots Q7Z7N6 P36639 Q9UBM0 Q6P0Y6 A4D205 Q9UBM9 Q6LES7 Q8IV95
Accessions ABB02181 BAA07601 EAL23948 EAL23949 EAW87225 EAW87226 EAW87227 EAW87228 EAW87229 EAW87230 EAW87231 EAW87232 P36639 AB025233 BAA83791 AB025234 BAA83792 AB025235 BAA83793 AB025236 BAA83794 AB025237 BAA83795 AB025238 BAA83796 AB025239 BAA83797 AB025240 BAA83798 AB025241 BAA83799 AB025242 BAA83800 AK026631 BC014618 AAH14618 BC022818 BC040144 AAH40144 BC051375 AAH51375 BC065367 AAH65367 BM927392 CR407655 CAG28583 D16581 BAA04013 NM_002452 NP_002443 NM_198948 NP_945186 NM_198949 NP_945187 NM_198950 NP_945188 NM_198952 NP_945190 NM_198953 NP_945191 NM_198954 NP_945192
Function Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. {ECO:0000269|PubMed:10373420, ECO:0000269|PubMed:10608900, ECO:0000269|PubMed:11139615, ECO:0000269|PubMed:12857738, ECO:0000269|PubMed:22556419}.
Subcellular Location Isoform p18: Cytoplasm. Mitochondrion matrix. Nucleus. Note=Mostly present in cytoplasm. Variant Met-124 has decreased efficiency in translocation to mitochondria.
Tissue Specificity Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes. {ECO:0000269|PubMed:9211940}.

MTH1 CRISPR/Cas9 KO Plasmid (h) - sc-403105 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTH1 HDR Plasmid (h) - sc-403105-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTH1 Double Nickase Plasmid (h) - sc-403105-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTH1 Double Nickase Plasmid (h2) - sc-403105-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTH1 CRISPR Activation Plasmid (h) - sc-403105-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTH1 CRISPR Activation Plasmid (h2) - sc-403105-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTH1 Lentiviral Activation Particles (h) - sc-403105-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTH1 Lentiviral Activation Particles (h2) - sc-403105-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTH1 siRNA (h) - sc-62647 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MTH1 shRNA Plasmid (h) - sc-62647-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MTH1 shRNA (h) Lentiviral Particles - sc-62647-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MTH1 RNAi - H00004521-R07 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MTH1 RNAi - H00004521-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MTH1 RNAi - H00004521-R06 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MTH1 RNAi - H00004521-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MTH1 RNAi - H00004521-R05 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MTH1 RNAi - H00004521-R04 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU123931 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1492 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1492 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00252 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00252

NUDT1 siRNA (Human) - CRH3000 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MTH1 RNAi - H00004521-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human NUDT1 (NM_002452.3) - SHH356008 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human NUDT1(NM_002452.3) - SHR025544 from Creative biogene

Category siRNA
Species Reactivities Human
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