NUDT1

Gene Symbol NUDT1
Entrez Gene 4521
Alt Symbol MTH1
Species Human
Gene Type protein-coding
Description nudix (nucleoside diphosphate linked moiety X)-type motif 1
Other Description 2-hydroxy-dATP diphosphatase|7,8-dihydro-8-oxoguanine triphosphatase|8-oxo-7,8-dihydrodeoxyguanosine triphosphatase|8-oxo-7,8-dihydroguanosine triphosphatase|8-oxo-dGTPase|mutT human homolog 1|nucleoside diphosphate-linked moiety X motif 1|nucleoside diphosphate-linked moiety X-type motif 1|nudix motif 1
Swissprots Q7Z7N6 P36639 Q9UBM0 Q6P0Y6 A4D205 Q9UBM9 Q6LES7 Q8IV95
Accessions ABB02181 BAA07601 EAL23948 EAL23949 EAW87225 EAW87226 EAW87227 EAW87228 EAW87229 EAW87230 EAW87231 EAW87232 P36639 AB025233 BAA83791 AB025234 BAA83792 AB025235 BAA83793 AB025236 BAA83794 AB025237 BAA83795 AB025238 BAA83796 AB025239 BAA83797 AB025240 BAA83798 AB025241 BAA83799 AB025242 BAA83800 AK026631 BC014618 AAH14618 BC022818 BC040144 AAH40144 BC051375 AAH51375 BC065367 AAH65367 BM927392 CR407655 CAG28583 D16581 BAA04013 NM_002452 NP_002443 NM_198948 NP_945186 NM_198949 NP_945187 NM_198950 NP_945188 NM_198952 NP_945190 NM_198953 NP_945191 NM_198954 NP_945192
Function Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. {ECO:0000269|PubMed:10373420, ECO:0000269|PubMed:10608900, ECO:0000269|PubMed:11139615, ECO:0000269|PubMed:12857738, ECO:0000269|PubMed:22556419}.
Subcellular Location Isoform p18: Cytoplasm. Mitochondrion matrix. Nucleus. Note=Mostly present in cytoplasm. Variant Met-124 has decreased efficiency in translocation to mitochondria.
Tissue Specificity Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes. {ECO:0000269|PubMed:9211940}.

Human-NUDT1-cDNA-Clone - DC07864 from Abgent, a WuXi AppTec company

Prices $241.65
Sizes 10 µg
Species Human
Accession BC014618

NUDT1 - MBS1274915 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC014618

NUDT1 - MBS1274051 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC051375

Human NUDT1 cDNA clone(NM_198949.1) - CDFG012988 from Creative Biomart

Species Human
Accession NM_198949.1

Human NUDT1 cDNA clone(NM_198948.1) - CDFG012989 from Creative Biomart

Species Human
Accession NM_198948.1

Human NUDT1 cDNA clone(NM_198950.1) - CDFG012991 from Creative Biomart

Species Human
Accession NM_198950.1

Human NUDT1 cDNA clone(NM_198953.1) - CDFG012992 from Creative Biomart

Species Human
Accession NM_198953.1

Human NUDT1 cDNA clone(NM_198952.1) - CDFG012994 from Creative Biomart

Species Human
Accession NM_198952.1

Human NUDT1 cDNA clone(NM_198954.1) - CDFG012996 from Creative Biomart

Species Human
Accession NM_198954.1

Human NUDT1 cDNA clone(NM_002452.3) - CDFH012960 from Creative Biomart

Species Human
Accession NM_002452.3

Human NUDT1 ORF Clone(NM_002452.3) - CDCR283208 from Creative Biomart

Species Human
Accession NM_002452.3

Human NUDT1 ORF Clone(NM_002452.3) - CDCR283209 from Creative Biomart

Species Human
Accession NM_002452.3

Human NUDT1 ORF Clone(NM_198948.1) - CDCR326394 from Creative Biomart

Species Human
Accession NM_198948.1

Human NUDT1 ORF Clone(NM_198948.1) - CDCR326395 from Creative Biomart

Species Human
Accession NM_198948.1

Human NUDT1 ORF Clone(NM_198949.1) - CDCR326396 from Creative Biomart

Species Human
Accession NM_198949.1

Human NUDT1 ORF Clone(NM_198949.1) - CDCR326397 from Creative Biomart

Species Human
Accession NM_198949.1

Human NUDT1 ORF Clone(NM_198950.1) - CDCR326398 from Creative Biomart

Species Human
Accession NM_198950.1

Human NUDT1 ORF Clone(NM_198950.1) - CDCR326399 from Creative Biomart

Species Human
Accession NM_198950.1

Human NUDT1 ORF Clone(NM_198952.1) - CDCR326402 from Creative Biomart

Species Human
Accession NM_198952.1

Human NUDT1 ORF Clone(NM_198952.1) - CDCR326403 from Creative Biomart

Species Human
Accession NM_198952.1

Human NUDT1 ORF Clone(NM_198952.1) - CDCR326404 from Creative Biomart

Species Human
Accession NM_198952.1

Human NUDT1 ORF Clone(NM_198953.1) - CDCR326405 from Creative Biomart

Species Human
Accession NM_198953.1

Human NUDT1 ORF Clone(NM_198953.1) - CDCR326406 from Creative Biomart

Species Human
Accession NM_198953.1

Human NUDT1 ORF Clone(NM_198954.1) - CDCR326407 from Creative Biomart

Species Human
Accession NM_198954.1

Human NUDT1 ORF Clone(NM_198954.1) - CDCR326408 from Creative Biomart

Species Human
Accession NM_198954.1
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