NUDT1

Gene Symbol NUDT1
Entrez Gene 4521
Alt Symbol MTH1
Species Human
Gene Type protein-coding
Description nudix (nucleoside diphosphate linked moiety X)-type motif 1
Other Description 2-hydroxy-dATP diphosphatase|7,8-dihydro-8-oxoguanine triphosphatase|8-oxo-7,8-dihydrodeoxyguanosine triphosphatase|8-oxo-7,8-dihydroguanosine triphosphatase|8-oxo-dGTPase|mutT human homolog 1|nucleoside diphosphate-linked moiety X motif 1|nucleoside diphosphate-linked moiety X-type motif 1|nudix motif 1
Swissprots Q7Z7N6 P36639 Q9UBM0 Q6P0Y6 A4D205 Q9UBM9 Q6LES7 Q8IV95
Accessions ABB02181 BAA07601 EAL23948 EAL23949 EAW87225 EAW87226 EAW87227 EAW87228 EAW87229 EAW87230 EAW87231 EAW87232 P36639 AB025233 BAA83791 AB025234 BAA83792 AB025235 BAA83793 AB025236 BAA83794 AB025237 BAA83795 AB025238 BAA83796 AB025239 BAA83797 AB025240 BAA83798 AB025241 BAA83799 AB025242 BAA83800 AK026631 BC014618 AAH14618 BC022818 BC040144 AAH40144 BC051375 AAH51375 BC065367 AAH65367 BM927392 CR407655 CAG28583 D16581 BAA04013 NM_002452 NP_002443 NM_198948 NP_945186 NM_198949 NP_945187 NM_198950 NP_945188 NM_198952 NP_945190 NM_198953 NP_945191 NM_198954 NP_945192
Function Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. {ECO:0000269|PubMed:10373420, ECO:0000269|PubMed:10608900, ECO:0000269|PubMed:11139615, ECO:0000269|PubMed:12857738, ECO:0000269|PubMed:22556419}.
Subcellular Location Isoform p18: Cytoplasm. Mitochondrion matrix. Nucleus. Note=Mostly present in cytoplasm. Variant Met-124 has decreased efficiency in translocation to mitochondria.
Tissue Specificity Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes. {ECO:0000269|PubMed:9211940}.

NUDT1-Over-expression-Lysate - LY15853a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag NUDT1 (arrow) using his tag antibody. 293T cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the NUDT1 gene‘

NUDT1-Over-expression-Lysate - LY12941a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag NUDT1 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the NUDT1 gene

NUDT1 293T Cell Transient Overexpression Lysate(Denatured) - H00004521-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

NUDT1 293 Cell Lysate - 403402 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

NUDT1 293 Cell Lysate - 403403 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

MTH1 Overexpression Lysate (Denatured) - H00004521-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
Lane 1: NUDT1 transfected lysate (18 KDa) Lane 2: Non-transfected lysate.

MTH1 Overexpression Lysate (Native) - NBL1-13852 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: MTH1 Overexpression Lysate (Adult Normal) [NBL1-13852] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MTH1.

MTH1 (h): 293T Lysate - sc-112873 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

NUDT1 Over-expression Lysate Product - GWB-EDE8DB from Genway Biotech

Category Cell Lysate
Prices $445.00
Sizes 100 µg
Species Human

NUDT1 Over-expression Lysate Product - GWB-A87DC5 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

MTH1 Overexpression Lysate (Native) - NBP2-04636 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: MTH1 Overexpression Lysate (Adult Normal) [NBP2-04636] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MTH1.

MTH1 Overexpression Lysate (Native) - NBP2-04635 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: MTH1 Overexpression Lysate (Adult Normal) [NBP2-04635] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MTH1.

MTH1 Overexpression Lysate (Native) - NBP2-04634 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: MTH1 Overexpression Lysate (Adult Normal) [NBP2-04634] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MTH1.

MTH1 Overexpression Lysate (Native) - NBP2-04633 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: MTH1 Overexpression Lysate (Adult Normal) [NBP2-04633] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MTH1.

MTH1 Overexpression Lysate (Native) - NBP2-04632 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: MTH1 Overexpression Lysate (Adult Normal) [NBP2-04632] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MTH1.

Panoply™ Human NUDT1 Knockdown Stable Cell Line - CSC-DC010701 from Creative biogene

Category Cell Line
Species Human

Human NUDT1 Knockout Cell Line-HEK293T - CSC-RT1061 from Creative biogene

Category Cell Line
Species Human

NUDT1 KO Cell Lysate-HEK293T - CLKO-0551 from Creative biogene

Category Cell Lysate
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