NUDT1

Gene Symbol	NUDT1
Entrez Gene	4521
Alt Symbol	MTH1
Species	Human
Gene Type	protein-coding
Description	nudix (nucleoside diphosphate linked moiety X)-type motif 1
Other Description	2-hydroxy-dATP diphosphatase|7,8-dihydro-8-oxoguanine triphosphatase|8-oxo-7,8-dihydrodeoxyguanosine triphosphatase|8-oxo-7,8-dihydroguanosine triphosphatase|8-oxo-dGTPase|mutT human homolog 1|nucleoside diphosphate-linked moiety X motif 1|nucleoside diphosphate-linked moiety X-type motif 1|nudix motif 1
Swissprots	Q7Z7N6 P36639 Q9UBM0 Q6P0Y6 A4D205 Q9UBM9 Q6LES7 Q8IV95
Accessions	ABB02181 BAA07601 EAL23948 EAL23949 EAW87225 EAW87226 EAW87227 EAW87228 EAW87229 EAW87230 EAW87231 EAW87232 P36639 AB025233 BAA83791 AB025234 BAA83792 AB025235 BAA83793 AB025236 BAA83794 AB025237 BAA83795 AB025238 BAA83796 AB025239 BAA83797 AB025240 BAA83798 AB025241 BAA83799 AB025242 BAA83800 AK026631 BC014618 AAH14618 BC022818 BC040144 AAH40144 BC051375 AAH51375 BC065367 AAH65367 BM927392 CR407655 CAG28583 D16581 BAA04013 NM_002452 NP_002443 NM_198948 NP_945186 NM_198949 NP_945187 NM_198950 NP_945188 NM_198952 NP_945190 NM_198953 NP_945191 NM_198954 NP_945192
Function	Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. {ECO:0000269|PubMed:10373420, ECO:0000269|PubMed:10608900, ECO:0000269|PubMed:11139615, ECO:0000269|PubMed:12857738, ECO:0000269|PubMed:22556419}.
Subcellular Location	Isoform p18: Cytoplasm. Mitochondrion matrix. Nucleus. Note=Mostly present in cytoplasm. Variant Met-124 has decreased efficiency in translocation to mitochondria.
Tissue Specificity	Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes. {ECO:0000269|PubMed:9211940}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MTH1 full length protein - ab99390 from Abcam Category Protein Source E. coli Species Human

MTH1 Recombinant Protein - H00004521-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human MTH1 Protein - NBP1-49309 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E.coli Species Human

NUDT1 Protein (OPPA02614) - OPPA02614 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg

NUDT1 protein - orb84835 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli Species Human

Human NUDT1 (His Tag) protein - orb232435 from Biorbyt Category Protein Prices $281.00, $527.00 Sizes 20 μg, 100 μg Species Human

NUDT1 peptide - orb218845 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

NUDT1 protein (His tag) - 80R-1504 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

MTH1 Blocking Peptide - abx064176 from Abbexa Category Peptide Species Human, Mouse, Rat

NUDT1 (1-156, His-tag) - AR09680PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

NUDT1 (1-156, His-tag) - AR09680PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

NUDT1 - H00004521-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NUDT1 - H00004521-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Nudix Type Motif 1, Human Recombinant - 228-12166-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

NUDT1, 1-156aa, Human, His tag, E.coli - 01-1884-1 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

NUDT1 fusion protein - Ag10103 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

NUDT1 fusion protein - Ag9802 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

NUDT1 Human - ENPS-017 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human NUDT1 - BP000681-ENZ-010 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

NUDT1, 1-156aa, Recombinant Protein - GWB-P1296I from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

NUDT1 Human Protein - GWB-BSP261 from Genway Biotech Category Protein Prices $75.00, $165.00, $3,230.00 Sizes 5 μg, 20 μg, 1000 μg Source Escherichia Coli. Species Human

Recombinant Human NUDT1, His-tagged - NUDT1-798H from Creative Biomart Category Protein Source E.coli .

Recombinant Human NUDT1, His-tagged - NUDT1-30252TH from Creative Biomart Category Protein Source E. coli

Recombinant Human NUDT1, GST-tagged - NUDT1-1398H from Creative Biomart Category Protein Source E.coli Species Human

NUDT1 - JNV-050 from Reagent Proteins Category Protein Prices $364.00, $2,898.00 Sizes 20.00 µg, 1 mg Source E.coli

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