NUDT1

Gene Symbol NUDT1
Entrez Gene 4521
Alt Symbol MTH1
Species Human
Gene Type protein-coding
Description nudix (nucleoside diphosphate linked moiety X)-type motif 1
Other Description 2-hydroxy-dATP diphosphatase|7,8-dihydro-8-oxoguanine triphosphatase|8-oxo-7,8-dihydrodeoxyguanosine triphosphatase|8-oxo-7,8-dihydroguanosine triphosphatase|8-oxo-dGTPase|mutT human homolog 1|nucleoside diphosphate-linked moiety X motif 1|nucleoside diphosphate-linked moiety X-type motif 1|nudix motif 1
Swissprots Q7Z7N6 P36639 Q9UBM0 Q6P0Y6 A4D205 Q9UBM9 Q6LES7 Q8IV95
Accessions ABB02181 BAA07601 EAL23948 EAL23949 EAW87225 EAW87226 EAW87227 EAW87228 EAW87229 EAW87230 EAW87231 EAW87232 P36639 AB025233 BAA83791 AB025234 BAA83792 AB025235 BAA83793 AB025236 BAA83794 AB025237 BAA83795 AB025238 BAA83796 AB025239 BAA83797 AB025240 BAA83798 AB025241 BAA83799 AB025242 BAA83800 AK026631 BC014618 AAH14618 BC022818 BC040144 AAH40144 BC051375 AAH51375 BC065367 AAH65367 BM927392 CR407655 CAG28583 D16581 BAA04013 NM_002452 NP_002443 NM_198948 NP_945186 NM_198949 NP_945187 NM_198950 NP_945188 NM_198952 NP_945190 NM_198953 NP_945191 NM_198954 NP_945192
Function Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. {ECO:0000269|PubMed:10373420, ECO:0000269|PubMed:10608900, ECO:0000269|PubMed:11139615, ECO:0000269|PubMed:12857738, ECO:0000269|PubMed:22556419}.
Subcellular Location Isoform p18: Cytoplasm. Mitochondrion matrix. Nucleus. Note=Mostly present in cytoplasm. Variant Met-124 has decreased efficiency in translocation to mitochondria.
Tissue Specificity Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes. {ECO:0000269|PubMed:9211940}.

MTH1 (H-159) - sc-67291 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MTH1 (H-159): sc-67291. Western blot analysis of MTH1 expression in Jurkat whole cell lysate.

MTH1 (H-1) - sc-271082 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MTH1 (H-1): sc-271082. Western blot analysis of MTH1 expression in non-transfected 293T: sc-117752 (A), mouse MTH1 transfected 293T: sc-121835 (B) and Jurkat (C) whole cell lysates.

Anti-MTH1 antibody - ab187531 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of rat lung tissue labelling MTH1 with ab187531 at 1/200. Magnification: 400x.

Anti-MTH1 antibody - ab197855 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of U2OS cells extracts immunoprecipitated using ab197855Lane 1: Input.Lane 2: Immunoprecipitation with control serum.Lane 3: Immunoprecipitation with ab197855 (5ul)

Anti-MTH1 antibody - ab191501 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MTH1 antibody (ab191501)Lane 1 : A549 whole cell lysateLane 2 : Mouse liver tissue lysateLane 3 : Rat brain tissue lysate

Anti-MTH1 antibody - ab103615 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-MTH1 antibody (ab103615) at 5 µg/ml + Human kidney tissue lysate at 50 µg

Anti-MTH1 antibody - ab55527 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab55527 MTH1 antibody at 1ug/ml.

Anti-MTH1 antibody - ab172043 from Abcam

Prices $376.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-MTH1 antibody (ab172043) at 1/500 dilutionLane 1 : MTH1 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-MTH1 antibody - ab98 from Abcam

Prices $373.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MTH1 antibody [EPR15934] - ab197028 from Abcam

Prices $347.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15934
All lanes : Anti-MTH1 antibody [EPR15934] (ab197028) at 1/2000 dilutionLane 1 : Jurkat (Human T cell leukemia cells from peripheral blood) whole cell lysateLane 2 : A549 (Human lung carcinoma) whole cell lysateLane 3 : Human fetal thymus lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilutiondeveloped using the ECL technique

Anti-MTH1 antibody [EPR15934-50] - ab200832 from Abcam

Prices $347.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15934-50
Anti-MTH1 antibody [EPR15934-50] (ab200832) at 1/5000 dilution + Jurkat (Human T cell leukemia cells from peripheral blood) whole cell lysate at 20 µgSecondaryAnti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1000 dilution

Anti-NUDT1 / MTH1 Antibody (C-Terminus, Biotin) - LS-C140789 from LifeSpan Bioscience

Prices $365.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NUDT1 / MTH1 Antibody (C-Terminus, DY650) - LS-C140790 from LifeSpan Bioscience

Prices $365.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NUDT1 / MTH1 Antibody (C-Terminus, HRP) - LS-C140792 from LifeSpan Bioscience

Prices $365.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NUDT1 / MTH1 Antibody (C-Terminus, DY488) - LS-C140791 from LifeSpan Bioscience

Prices $365.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NUDT1 / MTH1 Antibody (C-Terminus, DY550) - LS-C140793 from LifeSpan Bioscience

Prices $365.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NUDT1 / MTH1 Antibody - LS-C340933 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NUDT1 / MTH1 Antibody - LS-C341628 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NUDT1 / MTH1 Antibody IHC-plus™ - LS-B7800 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-NUDT1 / MTH1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7800 dilution 1:100.

Anti-NUDT1 / MTH1 Antibody (clone 5F11) - LS-C197715 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5F11
Western Blot analysis of NUDT1 expression in transfected 293T cell line by NUDT1 monoclonal antibody (M02), clone 5F11.Lane 1: NUDT1 transfected lysate(18 KDa).Lane 2: Non-transfected lysate.

Anti-NUDT1 / MTH1 Antibody - LS-C335577 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded rat lung using NUDT1 antibody at dilution of 1:200 (400x lens).

Anti-NUDT1 / MTH1 Antibody (C-Terminus) IHC-plus™ - LS-B264 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-NUDT1 / MTH1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B264 concentration 5 ug/ml.

MTH1 Antibody - NB100-109 from Novus Biologicals

Prices $129.00, $349.00
Sizes 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MTH1 Antibody [NB100-109] - Analysis of MTH1 in 1. Ntera2, 2. MCF7 cell lysate, 3. A431 cell lysate and 4. COS7 cell lysate.

MTH1 Antibody (5F11) - H00004521-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5F11
Western Blot: MTH1 Antibody (5F11) [H00004521-M02] - Analysis of NUDT1 expression in transfected 293T cell line by NUDT1 monoclonal antibody (M02), clone 5F11.Lane 1: NUDT1 transfected lysate(18 KDa).Lane 2: Non-transfected lysate.

MTH1 Antibody - H00004521-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: MTH1 Antibody [H00004521-D01P] - Analysis of NUDT1 expression in human kidney.
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