MOCS3

Gene Symbol	MOCS3
Entrez Gene	27304
Alt Symbol	UBA4
Species	Human
Gene Type	protein-coding
Description	molybdenum cofactor synthesis 3
Other Description	MPT synthase sulfurylase|UBA4, ubiquitin-activating enzyme E1 homolog|adenylyltransferase and sulfurtransferase MOCS3|molybdenum cofactor synthesis protein 3|molybdopterin synthase sulfurylase|ubiquitin-like modifier activating enzyme 4
Swissprots	O95396
Accessions	EAW75606 O95396 AF102544 AAC72412 AI942426 BC015939 AAH15939 BG105185 BQ188547 BY995583 DB452633 DQ892355 ABM83281 DQ895546 ABM86472 HY215239 NM_014484 NP_055299
Function	Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. {ECO:0000255|HAMAP-Rule:MF_03049, ECO:0000269|PubMed:15073332, ECO:0000269|PubMed:19017811}.
Subcellular Location	Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03049, ECO:0000269|PubMed:15073332}.
Top Pathways	Sulfur relay system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MOCS3 (H-60) - sc-367575 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

MOCS3 (N-20) - sc-85764 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MOCS3 (S-20) - sc-85765 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MOCS3 (37-X) - sc-100562 from Santa Cruz Biotechnology Prices $279.00 Sizes 50 µg/0.5 ml Host Mouse Clonality Monoclonal

Anti-MOCS3 antibody - ab57229 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-MOCS3 antibody - ab154107 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MOCS3 antibody - N-terminal - ab139062 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MOCS3 Antibody (aa40-66, Biotin) - LS-C223311 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MOCS3 Antibody (aa40-66, AP) - LS-C223309 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MOCS3 Antibody (aa40-66, APC) - LS-C223310 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MOCS3 Antibody (aa40-66, Azide-free, HRP) - LS-C223313 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MOCS3 Antibody (aa40-66, FITC) - LS-C223312 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MOCS3 Antibody (aa40-66, PE) - LS-C223314 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MOCS3 Antibody - LS-C309040 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-MOCS3 Antibody (clone 1C5-E8) - LS-C309039 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1C5-E8

Anti-MOCS3 Antibody (aa40-66) - LS-C323062 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MOCS3 Antibody - LS-C311013 from LifeSpan Bioscience Prices $475.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MOCS3 Antibody - LS-C311015 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MOCS3 Antibody (aa1-461, Azide-free) - LS-C327928 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

Anti-MOCS3 Antibody (aa40-66) - LS-C158160 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

MOCS3 Antibody - NBP2-17320 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MOCS3 Antibody - H00027304-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

MOCS3 Antibody - NBP2-14244 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MOCS3 Antibody - H00027304-D01P from Novus Biologicals Prices $399.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

MOCS3 Antibody (1C5-E8) - H00027304-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1C5-E8

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