MOCS3

Gene Symbol MOCS3
Entrez Gene 27304
Alt Symbol UBA4
Species Human
Gene Type protein-coding
Description molybdenum cofactor synthesis 3
Other Description MPT synthase sulfurylase|UBA4, ubiquitin-activating enzyme E1 homolog|adenylyltransferase and sulfurtransferase MOCS3|molybdenum cofactor synthesis protein 3|molybdopterin synthase sulfurylase|ubiquitin-like modifier activating enzyme 4
Swissprots O95396
Accessions EAW75606 O95396 AF102544 AAC72412 AI942426 BC015939 AAH15939 BG105185 BQ188547 BY995583 DB452633 DQ892355 ABM83281 DQ895546 ABM86472 HY215239 NM_014484 NP_055299
Function Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. {ECO:0000255|HAMAP-Rule:MF_03049, ECO:0000269|PubMed:15073332, ECO:0000269|PubMed:19017811}.
Subcellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03049, ECO:0000269|PubMed:15073332}.
Top Pathways Sulfur relay system

MOCS3 CRISPR/Cas9 KO Plasmid (h) - sc-407422 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MOCS3 HDR Plasmid (h) - sc-407422-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MOCS3 Double Nickase Plasmid (h) - sc-407422-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MOCS3 Double Nickase Plasmid (h2) - sc-407422-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MOCS3 CRISPR Activation Plasmid (h) - sc-407422-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MOCS3 CRISPR Activation Plasmid (h2) - sc-407422-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MOCS3 Lentiviral Activation Particles (h) - sc-407422-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MOCS3 Lentiviral Activation Particles (h2) - sc-407422-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MOCS3 RNAi - H00027304-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU122221 from Sigma-Aldrich

Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN14461 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14461 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08612 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08612

MOCS3 siRNA (Human) - CRH9070 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MOCS3 (NM_014484.3) - SHH343392 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human MOCS3(NM_014484.3) - SHH195221 from Creative biogene

Category siRNA
Species Reactivities Human

MOCS3 shRNA Plasmid (Human) - CHH9070 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MOCS3 miRNA 3'UTR clone - MiUTR1H-06377 from Creative biogene

Species Reactivities Human
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