MOCS3

Gene Symbol	MOCS3
Entrez Gene	27304
Alt Symbol	UBA4
Species	Human
Gene Type	protein-coding
Description	molybdenum cofactor synthesis 3
Other Description	MPT synthase sulfurylase|UBA4, ubiquitin-activating enzyme E1 homolog|adenylyltransferase and sulfurtransferase MOCS3|molybdenum cofactor synthesis protein 3|molybdopterin synthase sulfurylase|ubiquitin-like modifier activating enzyme 4
Swissprots	O95396
Accessions	EAW75606 O95396 AF102544 AAC72412 AI942426 BC015939 AAH15939 BG105185 BQ188547 BY995583 DB452633 DQ892355 ABM83281 DQ895546 ABM86472 HY215239 NM_014484 NP_055299
Function	Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. {ECO:0000255|HAMAP-Rule:MF_03049, ECO:0000269|PubMed:15073332, ECO:0000269|PubMed:19017811}.
Subcellular Location	Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03049, ECO:0000269|PubMed:15073332}.
Top Pathways	Sulfur relay system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MOCS3 293T Cell Transient Overexpression Lysate(Denatured) - H00027304-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

MOCS3 overexpression lysate - LY415243 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

MOCS3 293 Cell Lysate - 407181 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

MOCS3 Overexpression Lysate (Native) - NBL1-13176 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

MOCS3 Over-expression Lysate Product - GWB-F85552 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

MOCS3 Overexpression Lysate (Denatured) - H00027304-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

MOCS3 Overexpression Lysate (Denatured) - H00027304-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human MOCS3 Knockdown Stable Cell Line - CSC-DC009636 from Creative biogene Category Cell Line Species Human

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