MOCS3

Gene Symbol	MOCS3
Entrez Gene	27304
Alt Symbol	UBA4
Species	Human
Gene Type	protein-coding
Description	molybdenum cofactor synthesis 3
Other Description	MPT synthase sulfurylase|UBA4, ubiquitin-activating enzyme E1 homolog|adenylyltransferase and sulfurtransferase MOCS3|molybdenum cofactor synthesis protein 3|molybdopterin synthase sulfurylase|ubiquitin-like modifier activating enzyme 4
Swissprots	O95396
Accessions	EAW75606 O95396 AF102544 AAC72412 AI942426 BC015939 AAH15939 BG105185 BQ188547 BY995583 DB452633 DQ892355 ABM83281 DQ895546 ABM86472 HY215239 NM_014484 NP_055299
Function	Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. {ECO:0000255|HAMAP-Rule:MF_03049, ECO:0000269|PubMed:15073332, ECO:0000269|PubMed:19017811}.
Subcellular Location	Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03049, ECO:0000269|PubMed:15073332}.
Top Pathways	Sulfur relay system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Adenylyltransferase and sulfurtransferase MOCS3 (MOCS3), Human, ELISA Kit - E01A1921 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

MOCS3 (Human) Matched Antibody Pair - H00027304-AP11 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

MOCS3 (Human) Matched Antibody Pair - H00027304-AP21 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Adenylyltransferase and sulfurtransferase MOCS3 (MOCS3), ELISA Kit - MBS7227167 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyltransferase and sulfurtransferase MOCS3 (MOCS3), ELISA Kit - MBS7211556 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyltransferase and sulfurtransferase MOCS3 (MOCS3), ELISA Kit - MBS7226186 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyltransferase and sulfurtransferase MOCS3 (MOCS3), ELISA Kit - MBS7207505 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyltransferase and sulfurtransferase MOCS3 (MOCS3), ELISA Kit - MBS7233362 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyltransferase and sulfurtransferase MOCS3 (MOCS3), ELISA Kit - MBS7221600 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyltransferase and sulfurtransferase MOCS3 (MOCS3), ELISA Kit - MBS7208809 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyltransferase and sulfurtransferase MOCS3 (MOCS3), ELISA Kit - MBS7239279 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyltransferase and sulfurtransferase MOCS3 (MOCS3), ELISA Kit - MBS7205286 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyltransferase and sulfurtransferase MOCS3 (MOCS3), ELISA Kit - MBS7214258 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyltransferase and sulfurtransferase MOCS3 (MOCS3), ELISA Kit - MBS7250390 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyltransferase and sulfurtransferase MOCS3 (MOCS3), ELISA Kit - MBS7205098 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human MOCS3 ELISA Kit - E000888 from Biobool Category ELISA Kit

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